Inhibition of retinal ischemia-reperfusion injury in rats by inhalation of low-concentration hydrogen gas

Atsushi Hayashi, Kenichi Arai, Mitsuya Otsuka, Yoshiko Yoshida

Purpose: To investigate the inhibitory effect of hydrogen gas inhalation on retinal ischemia reperfusion (I/R) injury using a rat model. Methods: Six-week-old male Sprague-Dawley rats...

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Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway

Cong-Cong Zhang, Guang Shi, Jing Wang, Rong Chen, Xiang-Jian Zhang, Yuan-Yuan Du

This study explored the protective effect and mechanism of hydrogen‑rich saline (HRS) on the neurological function of mice with cerebral ischemia. Effects of HRS on...

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Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats

Huan Liu, Hui Yuan, Jianguo Li, Mengya Liu, Xiaoman Chen, Xiaoming Liu, Xiujun Qin, Yong Wang

Background: Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms...

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Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study

Alex Tarnava, Ghizal Fatima, Jan Fedacko, Ram B. Singh, Tyler W. LeBaron, Viliam Mojto

Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and...

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The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial

Feng Sun, Hong Bao, Hui Chen, Jie-Ming Qu, Meng-Meng Shi, Qing-Yun Li, Rong Chen, Ting Cheng, Wei-Ning Xiong, Xiao-Dan Wang, Yuan-Lin Song, Yun-Feng Zhang, Yun-Tian Chen

Clinical studies had found that hydrogen/oxygen mixed inhalation was beneficial to ameliorate the respiratory symptoms in the adjuvant treatment of patients with COVID-19. We aimed...

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Hydrogen prevents lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by inhibiting store-operated Ca2+ entry regulated by STIM1/Orai1

Guiyue Wang, Hongguang Chen, Ruichen Shu, Xuan Zhang, Yiqing Yin, Yuan Li

Background: Sepsis is a type of life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The lung is the most vulnerable...

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NIR-Activatable Heterostructured Nanoadjuvant Cop/Nicop Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy And Photoimmunotherapy

Bin Liu, binbin Ding, Chunzheng Yang, Jia Tan, Jiashi Zhang, Jun Lin, Meifang Wang, Meng Yuan, Mengyu Chang, Ping'an Ma, Yulong Bian, Zhendong Liu

Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic non-invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation...

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Fructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid decreases maternal and female fetal oxidative stress by increasing intestinal microbe-derived hydrogen gas

Akito Shimouchi, Asuka Okuda, Kenichi Tanabe, Sadako Nakamura, Toshiyuki Nakayama, Tsuneyuki Oku, Yuri Kintaka

Fructooligosaccharide (FOS) is fermented by intestinal microbes to generate intestinal microbe-derived hydrogen gas (IMDH). Oxidative stress increases during gestation, whereas hydrogen gas has antioxidant effects...

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Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis

Changjun Wang, Hongzhi Yang, Jiaying Dai, Jiean Xu, Jinwen Xu, Luyao Xu, Wei Liu, Wen Su, Wenhai Guo, Xiaodong Zhang, Ya Cheng, Yaxing Zhang, Yun Chen

Alcoholic liver disease (ALD), which is induced by chronic heavy alcohol consumption, accompanies complicated pathological mechanisms, including oxidative stress, inflammation, cell death, epigenetic changes and...

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Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports

Bunpei Sato, Fumitake Satoh, Shin-Ichi Hirano, Yoshiyasu Takefuji, Yusuke Ichikawa

No abstract available Publish Year 2024 Country Japan Rank Positive Journal Medical Gas Research Primary Topic Brain Secondary TopicChronic Fatigue Syndrome Model Human Tertiary TopicChronic...

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Efficacy and Safety of Hydrogen Therapy in Patients with Early-Stage Interstitial Lung Disease: A Single-Center, Randomized, Parallel-Group Controlled Trial

Chang Tang, Chenggong Guan, Fanping Yang, Haiqing Gao, Jin Yang, Lanting Wang, Li Ma, Lin Tang, Qiaozhi Gu, Shan He, Shengan Chen, Xiaoqun Luo, Ying Zhao, Yu Xu, Zhen Zhang, Zihua Chen

Purpose: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy...

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Hydrogen attenuates endothelial glycocalyx damage associated with partial cardiopulmonary bypass in rats

Hiroki Iwata, Sang Kien Truong, Shingo Kawashima, Soichiro Mimuro, Takasumi Katoh, Tsunehisa Sato, Yoshiki Nakajima

Cardiopulmonary bypass (CPB) causes systemic inflammation and endothelial glycocalyx damage. Hydrogen has anti-oxidant and anti-inflammatory properties; therefore, we hypothesized that hydrogen would alleviate endothelial glycocalyx...

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