Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers

Akinobu Taketomi, Hiroki Bochimoto, Kengo Shibata, Kosei Nakamura, Masato Fujiyoshi, Moto Fukai, Norio Kawamura, Shingo Shimada, Sodai Sakamoto, Sunao Fujiyoshi, Takahisa Ishikawa, Tsuyoshi Shimamura

We previously reported the efficacy of cold storage (CS) using a heavy water-containing solution (Dsol) and post-reperfusion hydrogen gas treatment separately. This study aimed to...

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The Role of LincRNA-EPS/Sirt1/Autophagy Pathway in the Neuroprotection Process by Hydrogen against OGD/R-Induced Hippocampal HT22 Cells Injury

Jianguo Feng, Jing Jia, Jun Zhou, Li Liu, Lu Tang, Shun Zhang, Ya-Hong Li, Ye Chen

Cerebral ischemia/reperfusion (CI/R) injury causes high disability and mortality. Hydrogen (H2) enhances tolerance to an announced ischemic event; however, the therapeutic targets for the effective...

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Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients with chronic periodontitis

Aarati Nayak, Akanksha Bhatt, Chetana Bogar, Kishore Bhat, Ranganath Nayak, Sachita Naik

Background: Activated inflammatory cells produce reactive oxygen species (ROS) to eliminate pathogens. Under normal conditions, the pathogens are taken care of, and tissues are repaired....

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Protective Effect of Hydrogen-Rich Saline on Spinal Cord Damage in Rats

Duried Alwazeer, Levent Aras, Levent Sahin, Murat Kayabas, Mustafa Makav, Serdar Yigit, Tyler W. LeBaron

The anti-inflammatory and anti-apoptotic effects of molecular hydrogen, delivered as hydrogen-rich saline (HRS), on spinal cord injury was investigated. Four-month-old male Sprague Dawley rats (n...

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Alleviating effects of hydrogen on hyperhomocysteinemia and fatty liver induced by high-methionine diet

Bo Wen, Jun-Yu Lu, Rong Fan, Tian-Qi Ding, Wen-Bin Chu, Xue-Wei Chen

Objective: To investigate the alleviating effect of hydrogen (H2) on homocysteine (Hcy) levels and non alcoholic fatty liver in rats with hyperhomocysteinemia (HHcy). Methods: After...

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Effects of hydrogen gas on NOD-like receptor protein 3 inflammasomes in the cerebral cortex of rats with traumatic brain injury

Hongtao Zhang, Jiwei Wang, Jun Chen, Lingling Liu, Yonghao Yu

Objective: To investigate the effect of hydrogen gas on NOD-like receptor protein 3 (NLRP3) inflammasomes in the cerebral cortex of rats with traumatic brain injury...

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Inflation using hydrogen improves donor lung quality by regulating mitochondrial function during cold ischemia phase

Bin Zheng, Guangchao Zhang, Huacheng Zhou, Le Duan, Lini Quan, Mengdi Zhang, Zhe Li

Background: Mitochondrial dysfunction results in poor organ quality, negatively affecting the outcomes of lung transplantation. Whether hydrogen benefits mitochondrial function in cold-preserved donors remain unclear....

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Hyperbaric oxygen combined with hydrogen-rich saline protects against acute lung injury

Lei Xue, Mingdong Wang, Qianyu Han, Siang Zhang, Xiaochen Bao, Xuewei Zhao, Yintao Chang, Yiqun Fang, Yuxiang Jin

Background: This study sought to investigate therapeutic effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO2) in an experimental rat model of acute lung...

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Hydrogen nanobubbles: A novel approach toward radio-sensitization agents

Habib Zaidi, Mahdi Kahani, Ramin Jaberi, Samaneh Hashemi, Seyed Mahmoud-Reza Aghamiri, Zahra Siavashpour

Background: Ocular melanoma is a rare kind of eye malignancy that threatens the patient's eyesight. Radiotherapy and surgical removal are the most commonly used therapeutic...

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Hydrogen Protection Boosts the Bioactivity of Chrysanthemum morifolium Extract in Preventing Palmitate-Induced Endothelial Dysfunction by Restoring MFN2 and Alleviating Oxidative Stress in HAEC Cells

Guanfei Zhang, Jiankang Liu, Lin Zhao, Min Wang, Oumeng Song, Xin Guo, Xuyun Liu, Yilin Gao

As the most important natural antioxidants in plant extracts, polyphenols demonstrate versatile bioactivities and are susceptible to oxidation. The commonly used ultrasonic extraction often causes...

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Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p

Jian Xiao, Wang Xi, Wei Li, Xiaofei Xue, Yufeng Zhang, Zhinong Wang

Aims: Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively...

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Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Atsunori Nakao, Hiromichi Naito, Ikuroh Ohsawa, Kohei Ageta, Masumi Iketani, Mizuki Seya, Toshiyuki Aokage, Ying Meng

Introduction: With the global population aging, there is an increased prevalence of sepsis among the elderly, a demographic particularly susceptible to inflammation. This study aimed...

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