Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis

Changjun Wang, Hongzhi Yang, Jiaying Dai, Jiean Xu, Jinwen Xu, Luyao Xu, Wei Liu, Wen Su, Wenhai Guo, Xiaodong Zhang, Ya Cheng, Yaxing Zhang, Yun Chen

Alcoholic liver disease (ALD), which is induced by chronic heavy alcohol consumption, accompanies complicated pathological mechanisms, including oxidative stress, inflammation, cell death, epigenetic changes and...

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Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports

Bunpei Sato, Fumitake Satoh, Shin-Ichi Hirano, Yoshiyasu Takefuji, Yusuke Ichikawa

No abstract available Publish Year 2024 Country Japan Rank Positive Journal Medical Gas Research Primary Topic Brain Secondary TopicChronic Fatigue Syndrome Model Human Tertiary TopicChronic...

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Efficacy and Safety of Hydrogen Therapy in Patients with Early-Stage Interstitial Lung Disease: A Single-Center, Randomized, Parallel-Group Controlled Trial

Chang Tang, Chenggong Guan, Fanping Yang, Haiqing Gao, Jin Yang, Lanting Wang, Li Ma, Lin Tang, Qiaozhi Gu, Shan He, Shengan Chen, Xiaoqun Luo, Ying Zhao, Yu Xu, Zhen Zhang, Zihua Chen

Purpose: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy...

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Hydrogen attenuates endothelial glycocalyx damage associated with partial cardiopulmonary bypass in rats

Hiroki Iwata, Sang Kien Truong, Shingo Kawashima, Soichiro Mimuro, Takasumi Katoh, Tsunehisa Sato, Yoshiki Nakajima

Cardiopulmonary bypass (CPB) causes systemic inflammation and endothelial glycocalyx damage. Hydrogen has anti-oxidant and anti-inflammatory properties; therefore, we hypothesized that hydrogen would alleviate endothelial glycocalyx...

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Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p

Jian Xiao, Wang Xi, Wei Li, Xiaofei Xue, Yufeng Zhang, Zhinong Wang

Aims: Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively...

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Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Atsunori Nakao, Hiromichi Naito, Ikuroh Ohsawa, Kohei Ageta, Masumi Iketani, Mizuki Seya, Toshiyuki Aokage, Ying Meng

Introduction: With the global population aging, there is an increased prevalence of sepsis among the elderly, a demographic particularly susceptible to inflammation. This study aimed...

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The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease

Anna Gvozdjakova, Branislav Kura, Jan Slezak, Jarmila Kucharska, Maria Szantova, Viliam Mojto, Zuzana Rausova, Zuzana Sumbalova

Molecular hydrogen (H2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology...

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Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults

Bogdan Andjelic, Darinka Korovljev, Marijana Ranisavljev, Nebojsa Kladar, Nikola Todorovic, Sergej M. Ostojic, Valdemar Stajer

Fecal short-chain fatty acids are responsive to oral hydrogen in overweight adults. Propionic acid significantly increased in participants who consumed hydrogen-rich water for 12 wk...

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Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study

Chao-Fang Chu, Feng-Cheng Liu, Frank L. Douglas, Hsia-Yun Chou, Jia-Ru Chung, Kuang-Yih Wang, Min-Chung Shen, Po-Jen Hsiao, Szu-Han Chiu, Tian-Yu Wang, Wei-Chih Huang, Wen-Wen Chen

Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high...

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RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-κB pathways

Jun-Song Chen, Wei Bao, Xiao-Wei Xi, Ye Yang, Yin-Ping Liu

Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in...

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Investigating the Effect of Hydrogen-Rich Water on Liver Cell Injury and Liver Cancer by Regulating GP73/ TGF-β Pathway

Jingwen Zhang, Luhao Chen, Shuai Jiang, Wanbin Chen, Xunbo Hou, Yan Liu, Yi Yang, Ying Xing, Yingwen Hou, Yuanren Gao

Background Liver cancer is an extremely heterogeneous malignant disease among tumors identified to date. In recent years, a large number of studies have found that...

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Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure

A.V. Deryugina, D.A. Danilova

We studied the effect of molecular hydrogen H2 on the content of circulating endothelial cells and the macrohistological structure of the heart in rats with...

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