Hydrogen–oxygen therapy can alleviate radiotherapy-induced hearing loss in patients with nasopharyngeal cancer

Duanming Du, Feng Mu, Jibing Chen, Kecheng Xu, Tianyu Lu, Xiaofeng Kong

Three patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12, 2, and 0.5 years after radiotherapy, respectively. The secretions subsided after conventional drug and...

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Micromotor-Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy

Fei Peng, Hanfeng Qin, Huaan Li, Jia Sun, Jiamiao Jiang, Junbin Gao, Kun Liu, Ruotian Zhang, Weichang Huang, Wenxin Xu, Yanzhen Song, Yicheng Ye, Yingfeng Tu, Yunrui Hu

Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single...

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The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Duried Alwazeer, Ebru Karadag Sari, Menekse Bulut, Mushap Kuru, Mustafa Makav, Sukran Yediel Aras

Research question: What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)? Design: Female rats were divided into four groups, each...

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The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa

Meizhu Chen, Qian Ye, Sheng Zhang, Weiming Yan, Xiaohong Chen, Xingchui Lin, Yanjian Chen, Yunpeng Wang

Objective: To investigate the feasibility and effectiveness of hydrogen in the treatment of retinitis pigmentosa (RP) patients through the drinking of hydrogen-rich water (HRW). Methods:...

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Inhibition of retinal ischemia-reperfusion injury in rats by inhalation of low-concentration hydrogen gas

Atsushi Hayashi, Kenichi Arai, Mitsuya Otsuka, Yoshiko Yoshida

Purpose: To investigate the inhibitory effect of hydrogen gas inhalation on retinal ischemia reperfusion (I/R) injury using a rat model. Methods: Six-week-old male Sprague-Dawley rats...

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Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway

Cong-Cong Zhang, Guang Shi, Jing Wang, Rong Chen, Xiang-Jian Zhang, Yuan-Yuan Du

This study explored the protective effect and mechanism of hydrogen‑rich saline (HRS) on the neurological function of mice with cerebral ischemia. Effects of HRS on...

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Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats

Huan Liu, Hui Yuan, Jianguo Li, Mengya Liu, Xiaoman Chen, Xiaoming Liu, Xiujun Qin, Yong Wang

Background: Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms...

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Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study

Alex Tarnava, Ghizal Fatima, Jan Fedacko, Ram B. Singh, Tyler W. LeBaron, Viliam Mojto

Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and...

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The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial

Feng Sun, Hong Bao, Hui Chen, Jie-Ming Qu, Meng-Meng Shi, Qing-Yun Li, Rong Chen, Ting Cheng, Wei-Ning Xiong, Xiao-Dan Wang, Yuan-Lin Song, Yun-Feng Zhang, Yun-Tian Chen

Clinical studies had found that hydrogen/oxygen mixed inhalation was beneficial to ameliorate the respiratory symptoms in the adjuvant treatment of patients with COVID-19. We aimed...

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Hydrogen prevents lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by inhibiting store-operated Ca2+ entry regulated by STIM1/Orai1

Guiyue Wang, Hongguang Chen, Ruichen Shu, Xuan Zhang, Yiqing Yin, Yuan Li

Background: Sepsis is a type of life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The lung is the most vulnerable...

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NIR-Activatable Heterostructured Nanoadjuvant Cop/Nicop Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy And Photoimmunotherapy

Bin Liu, binbin Ding, Chunzheng Yang, Jia Tan, Jiashi Zhang, Jun Lin, Meifang Wang, Meng Yuan, Mengyu Chang, Ping'an Ma, Yulong Bian, Zhendong Liu

Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic non-invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation...

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Fructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid decreases maternal and female fetal oxidative stress by increasing intestinal microbe-derived hydrogen gas

Akito Shimouchi, Asuka Okuda, Kenichi Tanabe, Sadako Nakamura, Toshiyuki Nakayama, Tsuneyuki Oku, Yuri Kintaka

Fructooligosaccharide (FOS) is fermented by intestinal microbes to generate intestinal microbe-derived hydrogen gas (IMDH). Oxidative stress increases during gestation, whereas hydrogen gas has antioxidant effects...

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