Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p

Jian Xiao, Wang Xi, Wei Li, Xiaofei Xue, Yufeng Zhang, Zhinong Wang

Aims: Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively...

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Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Atsunori Nakao, Hiromichi Naito, Ikuroh Ohsawa, Kohei Ageta, Masumi Iketani, Mizuki Seya, Toshiyuki Aokage, Ying Meng

Introduction: With the global population aging, there is an increased prevalence of sepsis among the elderly, a demographic particularly susceptible to inflammation. This study aimed...

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The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease

Anna Gvozdjakova, Branislav Kura, Jan Slezak, Jarmila Kucharska, Maria Szantova, Viliam Mojto, Zuzana Rausova, Zuzana Sumbalova

Molecular hydrogen (H2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology...

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Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults

Bogdan Andjelic, Darinka Korovljev, Marijana Ranisavljev, Nebojsa Kladar, Nikola Todorovic, Sergej M. Ostojic, Valdemar Stajer

Fecal short-chain fatty acids are responsive to oral hydrogen in overweight adults. Propionic acid significantly increased in participants who consumed hydrogen-rich water for 12 wk...

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Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study

Chao-Fang Chu, Feng-Cheng Liu, Frank L. Douglas, Hsia-Yun Chou, Jia-Ru Chung, Kuang-Yih Wang, Min-Chung Shen, Po-Jen Hsiao, Szu-Han Chiu, Tian-Yu Wang, Wei-Chih Huang, Wen-Wen Chen

Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high...

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RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-κB pathways

Jun-Song Chen, Wei Bao, Xiao-Wei Xi, Ye Yang, Yin-Ping Liu

Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in...

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Investigating the Effect of Hydrogen-Rich Water on Liver Cell Injury and Liver Cancer by Regulating GP73/ TGF-β Pathway

Jingwen Zhang, Luhao Chen, Shuai Jiang, Wanbin Chen, Xunbo Hou, Yan Liu, Yi Yang, Ying Xing, Yingwen Hou, Yuanren Gao

Background Liver cancer is an extremely heterogeneous malignant disease among tumors identified to date. In recent years, a large number of studies have found that...

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Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure

A.V. Deryugina, D.A. Danilova

We studied the effect of molecular hydrogen H2 on the content of circulating endothelial cells and the macrohistological structure of the heart in rats with...

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Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model

Alex Tarnava, Amir Avan, Ghazaleh Khalili-Tanha, Mahdieh Darroudi, Majid Khazaei, Nima Khalili-Tanha, Seyedeh Elnaz Nazari, Tyler W. LeBaron

Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle...

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Hydrogen–oxygen therapy can alleviate radiotherapy-induced hearing loss in patients with nasopharyngeal cancer

Duanming Du, Feng Mu, Jibing Chen, Kecheng Xu, Tianyu Lu, Xiaofeng Kong

Three patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12, 2, and 0.5 years after radiotherapy, respectively. The secretions subsided after conventional drug and...

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Micromotor-Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy

Fei Peng, Hanfeng Qin, Huaan Li, Jia Sun, Jiamiao Jiang, Junbin Gao, Kun Liu, Ruotian Zhang, Weichang Huang, Wenxin Xu, Yanzhen Song, Yicheng Ye, Yingfeng Tu, Yunrui Hu

Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single...

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The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Duried Alwazeer, Ebru Karadag Sari, Menekse Bulut, Mushap Kuru, Mustafa Makav, Sukran Yediel Aras

Research question: What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)? Design: Female rats were divided into four groups, each...

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