Hydrogen attenuates endothelial glycocalyx damage associated with partial cardiopulmonary bypass in rats

Hiroki Iwata, Sang Kien Truong, Shingo Kawashima, Soichiro Mimuro, Takasumi Katoh, Tsunehisa Sato, Yoshiki Nakajima

Cardiopulmonary bypass (CPB) causes systemic inflammation and endothelial glycocalyx damage. Hydrogen has anti-oxidant and anti-inflammatory properties; therefore, we hypothesized that hydrogen would alleviate endothelial glycocalyx...

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Production, metabolism, and excretion of hydrogen in the large intestine

G.R. Gibson, J.H. Cummings, P.R. Murgatroyd, S.U. Christl

Hydrogen is produced during fermentation in the large intestine and may be excreted in breath and flatus or further metabolized by the flora. However, there...

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Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes

Bunpei Sato, Chi Liu, Masayuki Fujino, Ryosuke Kurokawa, Shinichi Hirano, Xiao-Kang Li

Hydrogen exerts beneficial effects in disease animal models of ischemia-reperfusion injury as well as inflammatory and neurological disease. Additionally, molecular hydrogen is useful for various...

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Production and Excretion of Hydrogen Gas in Man

Magnesium hydride (MGH), a highly promising hydrogen-producing substance/additive for hydrogen production through its hydrolysis reaction, has the potential to enhance broiler production. However, before incorporating MGH as a hydrogen-producing ...

Technics employing intestinal infusions of gas were used to study H2 production in the human intestine. The volume of H2 in the bowel of 10...

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Abstract A48: Changes In Hydrogen Gas Release From The Skin During Inhalation Of Hydrogen-Rich Air

Akito Shimouchi, Kazutoshi Nose

No abstract available Publish Year 2011 Country Japan Rank Neutral Journal American Thoracic Society International Conference Primary Topic Whole Body Secondary TopicHydrogen Biology Model Human...

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Pharmacokinetics of a single inhalation of hydrogen gas in pigs

Akeo Hirai, Eiji Kobayashi, Genki Ichihara, Mizuki Momoi, Motoaki Sano, Shigeo Ohata, Takahiro Hiraide, Tomoyoshi Tamura, Yoshinori Katsumata

The benefits of inhaling hydrogen gas (H2) have been widely reported but its pharmacokinetics have not yet been sufficiently analyzed. We developed a new experimental...

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Low-Flow Nasal Cannula Hydrogen Therapy

Eiji Kobayashi, Genki Ichihara, Kohsuke Shirakawa, Motoaki Sano, Yoshinori Katsumata

Background: Molecular hydrogen (H2) is a biologically active gas that is widely used in the healthcare sector. In recent years, on-site H2 gas generators, which...

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Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas

Akito Shimouchi, Dock-Chil Che, Kazutoshi Nose, Mikiyasu Shirai, Tomoe Mizukami

Inhaling or ingesting hydrogen (H2) gas improves oxidative stress-induced damage in animal models and humans. We previously reported that H2 was consumed throughout the human...

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Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water

Akito Shimouchi, Kazutoshi Nose, Mikiyasu Shirai, Takahara Kondo

Recent studies have revealed that inhaled or ingested hydrogen gas (H 2) inactivates reactive oxygen species such as hydroxyl radicals in various kinds of diseases...

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Breath hydrogen produced by ingestion of commercial hydrogen water and milk

Akito Shimouchi, Hiroshi Ishiguro, Kazutoshi Nose, Makoto Yamaguchi, Takahara Kondo

Objective: To compare how and to what extent ingestion of hydrogen water and milk increase breath hydrogen in adults. Methods: Five subjects without specific diseases,...

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Magnesium Particles Coated with Mesoporous Nanoshells as Sustainable Therapeutic-Hydrogen Suppliers to Scavenge Continuously Generated Hydroxyl Radicals in Long Term

Chuanrui Chen, Fangzhi Mou, Jianguo Guan, Lei Kong, Ming You, Yixia Yin, Yizheng Feng

Sustainable supplementation of massive molecular‐H2 is considered to be the most effective therapy for long‐term elimination of excessive hydroxyl radicals (·OH) in vivo, but has...

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In vivo quantification of hydrogen gas concentration in bone marrow surrounding magnesium fracture fixation hardware using an electrochemical hydrogen gas sensor

Andrew Brown, Charles Sfeir, Daoli Zhao, Sayuri Yoshizawa, Tingting Wang, William R. Heineman

Statement of significance: An electrochemical H2 sensor was used to monitor the degradation of a Mg fracture fixation system in a lapine ulna fracture model....

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