Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis

Binyi An, Fang Liu, Hong Sang, Nan Hong, Pan Yu, Qingtao Kong, Xinyu Zhang, Yingying Wu, Yuxin Shan

The purpose of this study was to investigate whether hydrogen-rich bath has therapeutic effect on psoriasis and its molecular mechanism. Mice with imiquimod-induced psoriasis were...

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Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-Arm, Retrospective Study

Hongxiang Ji, Ruitao Sun, Tongshang Ni, Xiaoheng Ding, Yuquan Li, Zeyu Liu, Ziyi Zhao

Aim: To evaluate the real-life effectiveness and safety of Chinese patients with type 2 diabetes mellitus (T2DM) receiving hydrogen inhalation (HI) treatment as a supplementary...

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Hydrogen-generating Si-based agent improves fat graft survival in rats

Hikaru Kobayashi, Kazuya Kuroda, Koichi Tomita, Naoya Otani, Tateki Kubo, Yuki Kobayashi

Background: Regulating excessive inflammation and oxidative stress in fat grafting may improve retention rates. Hydrogen effectively combats oxidative stress and inflammation and reportedly inhibits ischemia-reperfusion...

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Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery

Chao Xia, Lingting Zeng, Min Zhao, Qianjun He, Shengqiang Chen, Shucun Qin, Zhaokui Jin

The metabolic disorder of hepatocytes in non-alcoholic fatty liver disease (NAFLD) leads to the formation of an iron pool which induces the Fenton reaction-derived ferroptosis...

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Hydrogen-rich water treatment targets RT1-Db1 and RT1-Bb to alleviate premature ovarian failure in rats

Lu Zhao, Shuai Zhang, Xiaoyin Meng, Yingmei Wang

Background: Premature ovarian failure (POF) is defined as the cessation of ovarian function before the age of 40 years, imposing a significant health burden on...

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Hydrogen-Rich Saline-A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro

Cong Zhang, Huimin Qiao, Jing Wang, Lan Yang, Lan Zhang, Linyu Chen, Peipei Zhang, Renhao Xu, Wei Jiang, Xiangjian Zhang, Yuanyuan Du

Background: Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3...

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Hydrogen-rich water reduces cell damage by reducing excessive autophagy in mouse neuronal cells after oxygen glucose deprivation/reoxygenation

Junling Tao, Shixin Li, Yehong Li, Ying Liu

Objective: To investigate whether hydrogen-rich water exerts a protective effect against cellular injury by affecting the level of autophagy after oxygen glucose deprivation/reoxygenation (OGD/R) in...

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Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study

Bing Liang, Dongyue Du, Hongbin Kang, Hua Li, Jiangang Long, Jianjiao Cui, Jiankang Liu, Le Shi, Mami Noda, Ning Yi, Ping Li, Shucun Qin, Xuejun Sun, Yue Xi

Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models....

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Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

Cheol-Su Kim, Eun Sook Jeong, Johny Bajgal, Kyu-Jae Lee, Md Habibur Rahman, Seong Hoon Goh, Subham Sharma, Yeon-Gyu Jang

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including...

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Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model

Eri Inoue, Kenichi Ohta, Kosuke Koyano, Kota Inoue, Makoto Arioka, Masaki Ueno, Shinji Nakamura, Takanori Miki, Takashi Kusaka, Takayuki Yokota, Toi Tsuchiya, Tsutomu Mitsuie, Yasuhiro Nakao, Yinmon Htun, Yukihiko Konishi

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns in both high- and low-income countries. The important determinants of its...

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Hydrogen Attenuates Inflammation by Inducing Early M2 Macrophage Polarization in Skin Wound Healing

Fei Xie, Mengyu Liu, Pengxiang Zhao, Shidong Lu, Xuemei Ma, Xujuan Zhang, Zisong Cai, Ziyi Liu

The heterogeneous and highly plastic cell populations of macrophages are important mediators of cellular responses during all stages of wound healing, especially in the inflammatory...

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A drug co-delivery platform made of magnesium-based micromotors enhances combination therapy for hepatoma carcinoma cells

Bohan Wang, Jing Li, Miao Feng, Qingtao Song, Wenjuan Liu, Xiaoyong Ding, Yilin Liu, Zhongwei Gu

Combination therapy is an emerging strategy to overcome multidrug resistance (MDR) in hepatocellular carcinoma (HCC) chemotherapy treatment. However, the passive diffusion in traditional delivery systems...

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