Effect of hydrogen/oxygen therapy for ordinary COVID-19 patients: a propensity-score matched case-control study

Jindong Shi, Junhong Jiang, Kai Wang, Nanshan Zhong, Weijie Guan, Xiaohua Chen, Xiaoping Tan, Xiaoting Ren, Xinyu Li, Xu Zou, Yingying Zeng, Zeguang Zheng, Zhijun Jie

Background: Hydrogen/oxygen therapy contribute to ameliorate dyspnea and disease progression in patients with respiratory diseases. Therefore, we hypothesized that hydrogen/oxygen therapy for ordinary coronavirus disease...

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In vitro fermentation properties of magnesium hydride and related modulation effects on broiler cecal microbiome and metabolome

Haiyan Yang, He Zhu, Heng Hu, Weijiang Zheng, Wen Yao

Magnesium hydride (MGH), a highly promising hydrogen-producing substance/additive for hydrogen production through its hydrolysis reaction, has the potential to enhance broiler production. However, before incorporating...

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Transcriptome analysis of hydrogen inhibits osteoclastogenesis of mouse bone marrow mononuclear cells

Hui Zeng, Wei Wang, Yong Liu, Yong Zeng

Hydrogen (H2) is a major biodegradation product of implanted magnesium (Mg) alloys that are commonly used in the healing of bone fractures. Our earlier study...

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EFFECT OF ACUTE HYDROGEN-RICH WATER INTAKE ON INTRAOCULAR PRESSURE IN HEALTHY SUBJECTS

E. Najmanova, F. Pluhacek, H. Manethova, M. Botek

Purposes: The primary aim of the study was to assess the response of intraocular pressure (IOP) to the acute ingestion of hydrogen-rich water (HRW) compared...

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Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans

Darinka Korovljev, Jelena Ostojic, Nikola Todorovic, Sergej M. Ostojic

Introduction: We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1...

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Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model

Hairui Xie, Jiang Du, John Sieh Dumbuya, Lili Liang, Qiyi Zeng, Siqi Li, Xinxin Chen

Sepsis-associated encephalopathy (SAE) is characterised by long-term cognitive impairment and psychiatric illness in sepsis survivors, associated with increased morbidity and mortality. There is a lack...

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Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p

Jian Xiao, Wang Xi, Wei Li, Xiaofei Xue, Yufeng Zhang, Zhinong Wang

Aims: Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively...

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Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Atsunori Nakao, Hiromichi Naito, Ikuroh Ohsawa, Kohei Ageta, Masumi Iketani, Mizuki Seya, Toshiyuki Aokage, Ying Meng

Introduction: With the global population aging, there is an increased prevalence of sepsis among the elderly, a demographic particularly susceptible to inflammation. This study aimed...

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The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease

Anna Gvozdjakova, Branislav Kura, Jan Slezak, Jarmila Kucharska, Maria Szantova, Viliam Mojto, Zuzana Rausova, Zuzana Sumbalova

Molecular hydrogen (H2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology...

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Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults

Bogdan Andjelic, Darinka Korovljev, Marijana Ranisavljev, Nebojsa Kladar, Nikola Todorovic, Sergej M. Ostojic, Valdemar Stajer

Fecal short-chain fatty acids are responsive to oral hydrogen in overweight adults. Propionic acid significantly increased in participants who consumed hydrogen-rich water for 12 wk...

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Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study

Chao-Fang Chu, Feng-Cheng Liu, Frank L. Douglas, Hsia-Yun Chou, Jia-Ru Chung, Kuang-Yih Wang, Min-Chung Shen, Po-Jen Hsiao, Szu-Han Chiu, Tian-Yu Wang, Wei-Chih Huang, Wen-Wen Chen

Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high...

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RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-κB pathways

Jun-Song Chen, Wei Bao, Xiao-Wei Xi, Ye Yang, Yin-Ping Liu

Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in...

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