Effects of hydrogen gas on NOD-like receptor protein 3 inflammasomes in the cerebral cortex of rats with traumatic brain injury

Hongtao Zhang, Jiwei Wang, Jun Chen, Lingling Liu, Yonghao Yu

Objective: To investigate the effect of hydrogen gas on NOD-like receptor protein 3 (NLRP3) inflammasomes in the cerebral cortex of rats with traumatic brain injury...

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Inflation using hydrogen improves donor lung quality by regulating mitochondrial function during cold ischemia phase

Bin Zheng, Guangchao Zhang, Huacheng Zhou, Le Duan, Lini Quan, Mengdi Zhang, Zhe Li

Background: Mitochondrial dysfunction results in poor organ quality, negatively affecting the outcomes of lung transplantation. Whether hydrogen benefits mitochondrial function in cold-preserved donors remain unclear....

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Hyperbaric oxygen combined with hydrogen-rich saline protects against acute lung injury

Lei Xue, Mingdong Wang, Qianyu Han, Siang Zhang, Xiaochen Bao, Xuewei Zhao, Yintao Chang, Yiqun Fang, Yuxiang Jin

Background: This study sought to investigate therapeutic effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO2) in an experimental rat model of acute lung...

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Hydrogen nanobubbles: A novel approach toward radio-sensitization agents

Habib Zaidi, Mahdi Kahani, Ramin Jaberi, Samaneh Hashemi, Seyed Mahmoud-Reza Aghamiri, Zahra Siavashpour

Background: Ocular melanoma is a rare kind of eye malignancy that threatens the patient's eyesight. Radiotherapy and surgical removal are the most commonly used therapeutic...

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Hydrogen Protection Boosts the Bioactivity of Chrysanthemum morifolium Extract in Preventing Palmitate-Induced Endothelial Dysfunction by Restoring MFN2 and Alleviating Oxidative Stress in HAEC Cells

Guanfei Zhang, Jiankang Liu, Lin Zhao, Min Wang, Oumeng Song, Xin Guo, Xuyun Liu, Yilin Gao

As the most important natural antioxidants in plant extracts, polyphenols demonstrate versatile bioactivities and are susceptible to oxidation. The commonly used ultrasonic extraction often causes...

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Space Station-like Composite Nanoparticles for Co-Delivery of Multiple Natural Compounds from Chinese Medicine and Hydrogen in Combating Sensorineural Hearing Loss

Chong Yu, Gang Chen, Hanqi Li, Kerui He, Liye Xia, Lu Wen, Ming Zhang, Pei Luo, Shibao Xie, Wenbin Xiao, Zeming Zhou, Zhifeng Zhang

Ototoxic drugs such as aminoglycoside antibiotics and cisplatin (CDDP) can cause sensorineural hearing loss (SNHL), which is closely related to oxidative stress and the acidification...

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Efficacy of donepezil plus hydrogen-oxygen mixture inhalation for treatment of patients with Alzheimer disease: A retrospective study

Haifeng Li, Jin Xie, Zhaojun Dan

To investigate the clinical effect of donepezil combined with hydrogen-oxygen mixture inhalation in the treatment of patients with Alzheimer disease (AD), a total of 273...

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APOA2: New Target for Molecular Hydrogen Therapy in Sepsis-Related Lung Injury Based on Proteomic and Genomic Analysis

Enquan Wang, Feier Wu, Hongguang Chen, Keliang Xie, Yan Fan, Yi Jiang, Yonghao Yu, Yu Song, Yuanlin Wang

Target biomarkers for H2 at both the protein and genome levels are still unclear. In this study, quantitative proteomics acquired from a mouse model were...

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Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery

Barbora Kalocayova, Branislav Kura, Denisa Snurikova, Ivo Gasparovic, Jan Slezak, Jana Vlkovicova, Jaroslav Luptak, Karel Frimmel, Matej Ondrusek, Michal Hulman, Norbert Vrbjar, Rastislav Sramaty, Tyler W. LeBaron, Vladan Hudec

Cardiac surgery-associated acute kidney injury (CS-AKI) is a common postoperative complication, mostly due increasing oxidative stress. Recently, molecular hydrogen (H2 gas), has also been applied...

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Coral calcium carried hydrogen ameliorates the severity of non-alcoholic steatohepatitis induced by a choline deficient high carbohydrate fat-free diet in elderly rats

Daisuke Ueda, Kuai Ma, Masayuki Fujino, Naotsugu Ichimaru, Neiki Nambu, Xiao-Kang Li, Xin Hu

Hydrogen has been reported to act as an antioxidant, anti-apoptosis and anti-inflammatory agent. Coral calcium carried hydrogen (G2-SUISO) is a safer and more convenient form...

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Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation

Alexandra Olimpio Siquera Cunha, Aline Alves Jesus, Evelin Capellari Carnio, Junia Lara de Deus, Luiz G. S. Branco, Mateus Ramos Amorim, Procopio Cleber Gama de Barcellos Filho, Ricardo Mauricio Leao, Rui Milton Patricio da Silva Junior

Sepsis is associated with numerous physiological and biochemical abnormalities that result in a life-threatening condition. The involvement of the Central Nervous System (CNS) during sepsis...

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Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

Beibei Dong, Wen Mi, Xiaoyin Meng, Yi Jiang, Yonghao Yu, Yuanyuan Bai, Yuechun Lu

Hydrogen (H2) can protect against blood‒brain barrier (BBB) damage in sepsis-associated encephalopathy (SAE), but the mechanism is still unclear. We examined whether it is related...

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