Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

Cheol-Su Kim, Eun Sook Jeong, Johny Bajgal, Kyu-Jae Lee, Md Habibur Rahman, Seong Hoon Goh, Subham Sharma, Yeon-Gyu Jang

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including...

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The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs

Dong-Dong Qi, Jian-Tao Zhang, Meng-Yuan Ding, Muhammad Abid Hayat, Tao Liu, Ting Wang

This study explored the effects of drinking Hydrogen-rich water (HRW) on skin wound healing in dogs. Eight circular wounds were analyzed in each dog. The...

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Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model

Eri Inoue, Kenichi Ohta, Kosuke Koyano, Kota Inoue, Makoto Arioka, Masaki Ueno, Shinji Nakamura, Takanori Miki, Takashi Kusaka, Takayuki Yokota, Toi Tsuchiya, Tsutomu Mitsuie, Yasuhiro Nakao, Yinmon Htun, Yukihiko Konishi

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns in both high- and low-income countries. The important determinants of its...

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Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis

Berengere J.C. Luthringer-Feyerabend, Hao Wang, Hongzhou Peng, Jiahua Ni, Jiazeng Xia, Jun Yan, Rui Zan, Weijie Cai, Weiping Ji, Wenhui Wang, Xiaonong Zhang, Yang Song

Hydrogen has been used to suppress tumor growth with considerable efficacy. Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic...

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Hydrogen Attenuates Inflammation by Inducing Early M2 Macrophage Polarization in Skin Wound Healing

Fei Xie, Mengyu Liu, Pengxiang Zhao, Shidong Lu, Xuemei Ma, Xujuan Zhang, Zisong Cai, Ziyi Liu

The heterogeneous and highly plastic cell populations of macrophages are important mediators of cellular responses during all stages of wound healing, especially in the inflammatory...

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Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats

Asami Matsumoto, Daniel M. Rolston, Junhwan Kim, Junichi Sasaki, Kei Hayashida, Kentaro Oka, Koichiro Homma, Koichiro Shinozaki, Lance B. Becker, Mitsuaki Nishikimi, Motomichi Takahashi, Muhammad Shoaib, Rishabh C. Choudhary, Ryosuke Takegawa, Santiago J. Miyara, Shuhei Eguchi, Tadashi Ariyoshi, Tai Yin, Tomoaki Aoki, Yusuke Endo

Background: Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial...

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A drug co-delivery platform made of magnesium-based micromotors enhances combination therapy for hepatoma carcinoma cells

Bohan Wang, Jing Li, Miao Feng, Qingtao Song, Wenjuan Liu, Xiaoyong Ding, Yilin Liu, Zhongwei Gu

Combination therapy is an emerging strategy to overcome multidrug resistance (MDR) in hepatocellular carcinoma (HCC) chemotherapy treatment. However, the passive diffusion in traditional delivery systems...

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Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice

Chuang Zhu, Hongli Yan, Li Yang, Lihua Song, Xinwen Ding, Yao Zhang

Purpose: Oxidative damage and intestinal flora dysbiosis play important roles in the progression of chronic ulcerative colitis (UC). This study explored the effect and mechanism...

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Effect of hydrogen/oxygen therapy for ordinary COVID-19 patients: a propensity-score matched case-control study

Jindong Shi, Junhong Jiang, Kai Wang, Nanshan Zhong, Weijie Guan, Xiaohua Chen, Xiaoping Tan, Xiaoting Ren, Xinyu Li, Xu Zou, Yingying Zeng, Zeguang Zheng, Zhijun Jie

Background: Hydrogen/oxygen therapy contribute to ameliorate dyspnea and disease progression in patients with respiratory diseases. Therefore, we hypothesized that hydrogen/oxygen therapy for ordinary coronavirus disease...

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Response of Escherichia coli to hydrogen nanobubbles: an in vitro evaluation using synchrotron infrared spectroscopy

Bin Li, Jie Cheng, Jin Zheng, Jinfang Lu, Jun Hu, Junhong Lu, Xueling Li, Yadi Wang

Hydrogen (H2)-rich water, an apparent source of molecular H2, is an emerging functional drink with many purported benefits for human health (Yang et al., 2020;...

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In vitro fermentation properties of magnesium hydride and related modulation effects on broiler cecal microbiome and metabolome

Haiyan Yang, He Zhu, Heng Hu, Weijiang Zheng, Wen Yao

Magnesium hydride (MGH), a highly promising hydrogen-producing substance/additive for hydrogen production through its hydrolysis reaction, has the potential to enhance broiler production. However, before incorporating...

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Abstract 556: Protective Effect of a Hydrogen-Rich Preservation Solution During Cold Ischemia in Rat Lung Transplantation

A. Aoyama, A. Takahagi, F. Gochi, H. Date, H. Kayawake, H. Motoyama, H. Yamagishi, J. Tokuno, M. Hamaji, M. Saito, R. Okabe, S. Hirano, S. Ueda, T. Chen-Yoshikawa

No abstract available Publish Year 2018 Country Japan Rank Positive Journal Journal of Heart and Lung Transplantation Primary Topic Lung Secondary TopicSurgery/Transplantation Model Rat Tertiary...

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