Transcriptome analysis of hydrogen inhibits osteoclastogenesis of mouse bone marrow mononuclear cells

Hui Zeng, Wei Wang, Yong Liu, Yong Zeng

Hydrogen (H2) is a major biodegradation product of implanted magnesium (Mg) alloys that are commonly used in the healing of bone fractures. Our earlier study...

Read Study Article coming soon

Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death

Chao Meng, Huacheng Zhou, Jiahang Zhang, Jinfeng Liu, Lin Deng, Wenzhi Li

Background: Successful amelioration of long-term warm ischemia lung injury in donors after cardiac death (DCDs) can remarkably improve outcomes. Hydrogen gas provides potent anti-inflammatory and...

Read Study Article coming soon

EFFECT OF ACUTE HYDROGEN-RICH WATER INTAKE ON INTRAOCULAR PRESSURE IN HEALTHY SUBJECTS

E. Najmanova, F. Pluhacek, H. Manethova, M. Botek

Purposes: The primary aim of the study was to assess the response of intraocular pressure (IOP) to the acute ingestion of hydrogen-rich water (HRW) compared...

Read Study Article coming soon

Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier

Bo Shao, Changqing Xu, Jie Qi, Li Ge, Sha Li, Shujing Sui, Shuman Liu, Wengang Song, Xinpei Wu, Xueqiang Sun, Yueran Ren, Zhenzhen Ruan

With the rapid development and high therapeutic efficiency and biosafety of gas-involving theranostics, hydrogen medicine has been particularly outstanding because hydrogen gas (H2), a microbial-derived...

Read Study Article coming soon

Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans

Darinka Korovljev, Jelena Ostojic, Nikola Todorovic, Sergej M. Ostojic

Introduction: We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1...

Read Study Article coming soon

A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl 4-Induced Chronic Liver Injury in Rats

Chunhua Chen, Huaicun Liu, Huiru Ding, Jianwei Wang, Jinyu Fang, Quancheng Cheng, Weiguang Zhang, Xuan Fang

As a small-molecule reductant substance, hydrogen gas has an obvious antioxidant function. It can selectively neutralize hydroxyl radicals (•OH) and peroxynitrite (ONOO•) in cells, reducing...

Read Study Article coming soon

Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model

Hairui Xie, Jiang Du, John Sieh Dumbuya, Lili Liang, Qiyi Zeng, Siqi Li, Xinxin Chen

Sepsis-associated encephalopathy (SAE) is characterised by long-term cognitive impairment and psychiatric illness in sepsis survivors, associated with increased morbidity and mortality. There is a lack...

Read Study Article coming soon

Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression

Jing-Ya Li, Man-Jia Liu, Ping An, Xiao-Chun Zhao, Yu-Qing You

Background: Post-stroke depression (PSD) severely affects recovery in patients with intracerebral hemorrhage (ICH). Although hydrogen gas (H2) exerts excellent neuroprotective effects in patients with ICH,...

Read Study Article coming soon

Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p

Jian Xiao, Wang Xi, Wei Li, Xiaofei Xue, Yufeng Zhang, Zhinong Wang

Aims: Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively...

Read Study Article coming soon

Hydrogen Attenuated Inflammation Response and Oxidative in Hypoxic Ischemic Encephalopathy via Nrf2 Mediated the Inhibition of NLRP3 and NF-κB

Kun Han, Pingzhu Wang, Yajiao Hu

Hypoxia and ischemia cause neonatal encephalopathy and brain injury and can further result in cerebral palsy, cognitive impairment, growth restriction, and epilepsy. Induction of neuroprotection...

Read Study Article coming soon

Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Atsunori Nakao, Hiromichi Naito, Ikuroh Ohsawa, Kohei Ageta, Masumi Iketani, Mizuki Seya, Toshiyuki Aokage, Ying Meng

Introduction: With the global population aging, there is an increased prevalence of sepsis among the elderly, a demographic particularly susceptible to inflammation. This study aimed...

Read Study Article coming soon

Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model

Ailyn Fadriquela, Cheol-Su Kim, Eun Sook Jeong, Huang-Un Kwon, In-Soo You, Johny Bajgai, Kyu-Jae Lee, Md Habibur Rahman, So-Yeon Lee, Subham Sharma

Oxidative stress (OS) is one of the causative factors in the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease (AD) and cognitive dysfunction. In the...

Read Study Article coming soon