Hydrogen-generating Si-based agent improves fat graft survival in rats

Hikaru Kobayashi, Kazuya Kuroda, Koichi Tomita, Naoya Otani, Tateki Kubo, Yuki Kobayashi

Background: Regulating excessive inflammation and oxidative stress in fat grafting may improve retention rates. Hydrogen effectively combats oxidative stress and inflammation and reportedly inhibits ischemia-reperfusion...

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Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis

Jingyi Shi, Junmei Zhou, Lulu Zheng, Qingfeng Sheng, Shenghua Yu, Xueli Wang, Zhibao Lv, Zhimei Gao

Background: Hydrogen is protective against intestinal injury in necrotizing enterocolitis (NEC), mainly through to alleviate inflammation response. The M1 macrophages can promote inflammation. We hypothesized...

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Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery

Chao Xia, Lingting Zeng, Min Zhao, Qianjun He, Shengqiang Chen, Shucun Qin, Zhaokui Jin

The metabolic disorder of hepatocytes in non-alcoholic fatty liver disease (NAFLD) leads to the formation of an iron pool which induces the Fenton reaction-derived ferroptosis...

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Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis

Qiang Wan, Tian Sun, Ting-Ting Li, Wan-Chao Yang, Wen-Zhi Li, Yue-Zhen Wang

Background: Traumatic brain injury (TBI)-induced acute lung injury (ALI) is a critical condition, and inflammation and apoptosis play essential roles. Molecular hydrogen (H2) exerts anti-inflammatory...

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Hydrogen-rich water treatment targets RT1-Db1 and RT1-Bb to alleviate premature ovarian failure in rats

Lu Zhao, Shuai Zhang, Xiaoyin Meng, Yingmei Wang

Background: Premature ovarian failure (POF) is defined as the cessation of ovarian function before the age of 40 years, imposing a significant health burden on...

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The condition of the hairline of Chinchilla lanigera after the introduction of a hydrogen antioxidant into the diet

Alexey Ivanov, Dmitry Petrov, Elena Panina

It was found that the inclusion of water enriched with molecular hydrogen into the diet of a long-tailed chinchilla changed the fur quality indicators. In...

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Hydrogen-Rich Saline-A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro

Cong Zhang, Huimin Qiao, Jing Wang, Lan Yang, Lan Zhang, Linyu Chen, Peipei Zhang, Renhao Xu, Wei Jiang, Xiangjian Zhang, Yuanyuan Du

Background: Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3...

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In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas

Bo-Yan Liu, Jun-Li Xue, Meng-Yu Zhang, Min Zhao, Ming-Yue Wang, Qian-Qian Gu, Shu-Cun Qin, Yun Wang

Medical effects of hydrogen have been reported in many studies. Due to difficulties in measuring hydrogen concentration in vivo after intake and high explosive risks...

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Hydrogen-rich water reduces cell damage by reducing excessive autophagy in mouse neuronal cells after oxygen glucose deprivation/reoxygenation

Junling Tao, Shixin Li, Yehong Li, Ying Liu

Objective: To investigate whether hydrogen-rich water exerts a protective effect against cellular injury by affecting the level of autophagy after oxygen glucose deprivation/reoxygenation (OGD/R) in...

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Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum

Li Xiao, Nobuhiko Miwa, Yoshiharu Tanaka

This study compared the effects of hydrogen-water (HW) bath on the oxygen radical absorption-based antioxidant capacity and the inflammatory indicator, C-reactive protein (CRP), in serum...

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Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study

Bing Liang, Dongyue Du, Hongbin Kang, Hua Li, Jiangang Long, Jianjiao Cui, Jiankang Liu, Le Shi, Mami Noda, Ning Yi, Ping Li, Shucun Qin, Xuejun Sun, Yue Xi

Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models....

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Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs

Akeo Hirai, Eiji Kobayashi, Genki Ichihara, Hidenori Moriyama, Hiroki Kitakata, Kenichiro Kinouchi, Mizuki Momoi, Motoaki Sano, Seien Ko, Yoshiki Shinya, Yoshinori Katsumata

Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich water in neuropsychiatric and endocrine...

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