Molecular Hydrogen Prevents Osteoclast Activation in a Glucocorticoid-Induced Osteoporosis Zebrafish Scale Model

Giuseppe Banfi, Marta Carnobali, Massimo Mariotti

Antioxidants represent a powerful tool for many human diseases and, in particular, molecular hydrogen has unique characteristics that make it a very promising therapeutic agent...

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Hydrogen inhalation attenuates lung contusion after blunt chest trauma in mice

Atsunori Nakao, Hiromichi Naito, Hirotsugu Yamamoto, Kohei Ageta, Kohei Tsukahara, Mizuki Seya, Takafumi Obara, Takahiro Hirayama, Tetsuya Yumoto, Toshiyuki Aokage, Tsuyoshi Nojima, Ying Meng

Background: Lung contusion caused by blunt chest trauma evokes a severe inflammatory reaction in the pulmonary parenchyma that may be associated with acute respiratory distress...

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Hydrogen Promotes the Effectiveness of Bone Mesenchymal Stem Cell Transplantation in Rats with Spinal Cord Injury

Bing Xiao, Chengwei Yang, Jianxin Wu, Shengchang Luo, Weiheng Wang, Yanhai Xi, Yuanyuan Qiu, Zhicai Shi

Although bone mesenchymal stem cell (BMSC) transplantation has been applied to the treatment of spinal cord injury (SCI), the effect is unsatisfactory due to the...

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Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway

Bo-Qiang Cao, Chun-Hua Hang, Cong Pang, Jia-Qing Sun, Jia-Tong Zhang, Juan Wang, Qi Zhu, Wei Li, Xiao-Jian Li, Yu-Hua Zhang, Yue Lu, Zheng Peng, Zong Zhuang

The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still poorly understood. In a clinical trial of inhaled hydrogen in patients with...

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Effects of hydrogen gas inhalation on L-DOPA-induced dyskinesia

Bruna M. Santos, Danyelle Silva-Amaral, Elaine Del Bel, Glauce C. Nascimento, Grant T. Harris, Joao F. Pedrazzi, Luiz G. S. Branco, Mariza Bortolanza

L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia is a side effect of Parkinson's disease treatment and it is characterized by atypical involuntary movements. A link between neuroinflammation and L-DOPA-induced...

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Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers

Akinobu Taketomi, Hiroki Bochimoto, Kengo Shibata, Kosei Nakamura, Masato Fujiyoshi, Moto Fukai, Norio Kawamura, Shingo Shimada, Sodai Sakamoto, Sunao Fujiyoshi, Takahisa Ishikawa, Tsuyoshi Shimamura

We previously reported the efficacy of cold storage (CS) using a heavy water-containing solution (Dsol) and post-reperfusion hydrogen gas treatment separately. This study aimed to...

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The Role of LincRNA-EPS/Sirt1/Autophagy Pathway in the Neuroprotection Process by Hydrogen against OGD/R-Induced Hippocampal HT22 Cells Injury

Jianguo Feng, Jing Jia, Jun Zhou, Li Liu, Lu Tang, Shun Zhang, Ya-Hong Li, Ye Chen

Cerebral ischemia/reperfusion (CI/R) injury causes high disability and mortality. Hydrogen (H2) enhances tolerance to an announced ischemic event; however, the therapeutic targets for the effective...

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Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients with chronic periodontitis

Aarati Nayak, Akanksha Bhatt, Chetana Bogar, Kishore Bhat, Ranganath Nayak, Sachita Naik

Background: Activated inflammatory cells produce reactive oxygen species (ROS) to eliminate pathogens. Under normal conditions, the pathogens are taken care of, and tissues are repaired....

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Protective Effect of Hydrogen-Rich Saline on Spinal Cord Damage in Rats

Duried Alwazeer, Levent Aras, Levent Sahin, Murat Kayabas, Mustafa Makav, Serdar Yigit, Tyler W. LeBaron

The anti-inflammatory and anti-apoptotic effects of molecular hydrogen, delivered as hydrogen-rich saline (HRS), on spinal cord injury was investigated. Four-month-old male Sprague Dawley rats (n...

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Alleviating effects of hydrogen on hyperhomocysteinemia and fatty liver induced by high-methionine diet

Bo Wen, Jun-Yu Lu, Rong Fan, Tian-Qi Ding, Wen-Bin Chu, Xue-Wei Chen

Objective: To investigate the alleviating effect of hydrogen (H2) on homocysteine (Hcy) levels and non alcoholic fatty liver in rats with hyperhomocysteinemia (HHcy). Methods: After...

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Effects of hydrogen gas on NOD-like receptor protein 3 inflammasomes in the cerebral cortex of rats with traumatic brain injury

Hongtao Zhang, Jiwei Wang, Jun Chen, Lingling Liu, Yonghao Yu

Objective: To investigate the effect of hydrogen gas on NOD-like receptor protein 3 (NLRP3) inflammasomes in the cerebral cortex of rats with traumatic brain injury...

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Inflation using hydrogen improves donor lung quality by regulating mitochondrial function during cold ischemia phase

Bin Zheng, Guangchao Zhang, Huacheng Zhou, Le Duan, Lini Quan, Mengdi Zhang, Zhe Li

Background: Mitochondrial dysfunction results in poor organ quality, negatively affecting the outcomes of lung transplantation. Whether hydrogen benefits mitochondrial function in cold-preserved donors remain unclear....

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