Rational Design of Platinum-Bismuth Sulfide Schottky Heterostructure for Sonocatalysis-Mediated Hydrogen Therapy

Bin Liu, Chunzheng Yang, Fang Li, Jun Lin, Ling Yang, Meng Yuan, Ping'an Ma, Shuang Liang, Yulong Bian, Zhuang Yang, Ziyong Cheng

Conventional sonodynamic therapy (SDT) is unavoidably limited by the tumor microenvironment although many sonosensitizers have been developed to improve them to a certain extent. Given...

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Diffusivity of various inert gases in rat skeletal muscle

A.C. Carles, J. Piiper, S.F. Perry, T. Kawashiro

Krogh's diffusion constant (K) was determined for various inert gases in isolated rat abdominal muscle at 37 degrees C by measuring the amount of gas...

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Solubility of various inert gases in rat skeletal muscle

A.C. Carles, J. Piiper, T. Kawashiro

For the determination of solubility coefficients, isolated rat abdominal muscles were equilibrated at 37 degrees C with various inert gases saturated with water vapor. After...

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Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation

Chan Lu, Fan Xin, Guohong Ruan, Qian Sun, Ronghe Chen, Xinan Wen

Oxidative stress and inflammation play an important role in hypertensive animals and patients. Hydrogen plays a role of antioxidation and anti-inflammation. Calcium and magnesium play...

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Mast Cells in Regeneration of the Skin in Burn Wound with Special Emphasis on Molecular Hydrogen Effect

Andrey Kostin, Dmitri Atiakshin, Dmitry Nikityuk, Igor Buchwalow, Mariya Soboleva, Markus Tiemann, Nataliya Alexeeva, Svetlana Klochkova, Viktoriya Shishkina

The mechanisms of regeneration for the fibrous component of the connective tissue of the dermis are still insufficiently studied. The aim of this study was...

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Hydrogen inhalation enhances autophagy via the AMPK/mTOR pathway, thereby attenuating doxorubicin-induced cardiac injur

Binmai Zhang, Feifei Gong, Lei Yang, Tianjiao Ma, Wei Yang, Xin Lv

Aims: Doxorubicin is a drug widely used in clinical cancer treatment, but severe cardiotoxicity limits its clinical application. Autophagy disorder is an important factor in...

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Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study

Hirohisa Ono, Shigeo Ohta, Yoji Nishijima

(1) Background: Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Hydrogen gas (H2) is a therapeutic medical gas with multiple functions such as...

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Effect of Hydrogen on AM Pyroptosis Induced by Severe Burns in Rats

Chao Qin, Hua Lin, Linlin Zhang, Ning Luo, Qingqing Han, Xin Wang, Yi Jiang, Yonghao Yu, Yue Zhao

Background: Hydrogen has anti-inflammatory and antioxidant effects and is beneficial to multiple organs. However, its effect on alveolar macrophage (AM) pyroptosis induced by burns is...

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Hydrogen inhalation ameliorates hepatic inflammation and modulates gut microbiota in rats with high-fat diet-induced non-alcoholic fatty liver disease

Boyan Liu, Jun-Li Xue, Min Zhao, Qianqian Gu, Shuchun Qin, Xiaoyi Zhang, Xiubin Jia, Yunbo Xie, Yunchao Liu

Nonalcoholic fatty liver disease (NAFLD) is a multisystem metabolic disease associated with gut microflora dysbiosis and inflammation. Hydrogen (H2) is a novel and effective antiinflammatory...

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Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial

HYBRID II Study Group, Koichiro Homma, Masaru Suzuki, Motoaki Sano, Tomoyoshi Tamura

Background: Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible...

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Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression

Haidong Wu, Jingyu Bao, Juntai Chen, Keguan Lai, Keliang Xie, Lixin Li, Xuejia Yang, Yang Zhang, Yonghao Yu

Background: Sepsis-associated encephalopathy (SAE) is a complication of the central nervous system in patients with sepsis. Currently, no effective treatment for sepsis is available. Hydrogen...

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Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function

Akinobu Taketomi, Hiroki Bochimoto, Kengo Shibata, Kosei Nakamura, Masato Fujiyoshi, Moto Fukai, Norio Kawamura, Nur Khatijah Mohd Zin, Shingo Shimada, Sodai Sakamoto, Sunao Fujiyoshi, Takahisa Ishikawa, Tsuyoshi Shimamura

Background: We have previously reported the efficacy of post-reperfusion H2 gas treatment in cold storage (CS) and subsequent reperfusion of the rat liver. The present...

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