Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression

Haidong Wu, Jingyu Bao, Juntai Chen, Keguan Lai, Keliang Xie, Lixin Li, Xuejia Yang, Yang Zhang, Yonghao Yu

Background: Sepsis-associated encephalopathy (SAE) is a complication of the central nervous system in patients with sepsis. Currently, no effective treatment for sepsis is available. Hydrogen...

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Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function

Akinobu Taketomi, Hiroki Bochimoto, Kengo Shibata, Kosei Nakamura, Masato Fujiyoshi, Moto Fukai, Norio Kawamura, Nur Khatijah Mohd Zin, Shingo Shimada, Sodai Sakamoto, Sunao Fujiyoshi, Takahisa Ishikawa, Tsuyoshi Shimamura

Background: We have previously reported the efficacy of post-reperfusion H2 gas treatment in cold storage (CS) and subsequent reperfusion of the rat liver. The present...

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Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition

Dazhi Guo, Fei Xie, Mengyu Liu, Mingzi Zhang, Pengxiang Zhao, Ruiliu Luo, Shuyi Pan, Xuemei Ma, Xujuan Zhang, Youbin Wang, Zheng Dang

Background: Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively...

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Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients

Hua Lin, Jian Du, Keliang Xie, Yan Cui, Yonghao Yu, Zhigang Tian

Purpose: Postoperative delirium is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic...

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The Effect of Molecular Hydrogen on Functional States of Erythrocytes in Rats with Simulated Chronic Heart Failure

Anna Vyacheslavovna Deryugina, Darya Andreevna Danilova, Vladimir Viktorovich Pichugin, Yurii Dmitrievich Brichkin

Molecular hydrogen has an anti-inflammatory and cardioprotective effect, which is associated with its antioxidant properties. Erythrocytes are subjected to oxidative stress in pathologies of the...

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High Concentration Hydrogen Mitigates Sepsis-Induced Acute Lung Injury in Mice by Alleviating Mitochondrial Fission and Dysfunction

Guolin Wang, Jiange Han, Jing Liang, Keliang Xie, Nan Zhao, Ruiqiang Sun, Wanjie Ma, Yan Cui, Yingning Li, Yonghao Yu, Yu Song

Background: Multiple organ failure (MOF) is the main cause of early death in septic shock. Lungs are among the organs that are affected in MOF,...

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Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

Chang Liu, Guangyu Ji, Haiyan Yang, Hengke Liu, Jiayingzi Wu, Mingsong Wang, Pei Wang, Peng Huang, Tianyu Yao, Xiansong Wang, Yan Gong

Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization, decreased angiogenesis...

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Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway

Jinhui Jia, Juan Li, Li Wan, Li Zhang, Liang Hu, Man-Lin Duan, Pan Yu, Peng Teng, Qian Li, Qilin Peng, Rumeng Jia, Shirong Ruan, Wen-Tao Liu, Xing Yang, Ya-Dan Shi, Yinbing Pan

Background: Postoperative pain is a serious clinical problem with a poorly understood mechanism, and lacks effective treatment. Hydrogen (H2) can reduce neuroinflammation; therefore, we hypothesize...

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Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet

Aya Morimoto, Ikuko Kato, Ken-Ichi Ohta, Kosuke Koyano, Makoto Arioka, Masaki Ueno, Saneyuki Yasuda, Shinji Nakamura, Sonoko Kondo, Takanori Miki, Takashi Kusaka, Tsutomu Mitsuie, Yasuhiro Nakao, Yinmon Htun, Yukihiko Konishi

We previously reported the neuroprotective potential of combined hydrogen (H2) gas ventilation therapy and therapeutic hypothermia (TH) by assessing the short-term neurological outcomes and histological...

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Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study

Hongxiang Ji, Ruitao Sun, Tongshang Ni, Yunsheng Zhao, Yuquan Li, Zeyu Liu, Ziyi Zhao

Aim: To analyze the effectiveness and safety of hydrogen inhalation (HI) therapy as an adjunct treatment in Chinese type 2 diabetes mellitus (T2DM) patients in...

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Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage

Hai-Ling Zhang, Hong-Li Yan, Jia-Ming Guo, Jia-Wen Wang, Jing-Yi Wang, Long Ma, Qi Shao, Shuo Tian, Xu-Guang Hu

Background: Excessive doses of electromagnetic radiation pose a negative impact on the central nervous system and lead to mental disorders. Molecular hydrogen can scavenge intracellular...

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Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress

Erika Takemasa, Masaki Mogi, Naohito Hato, Shuang Liu, Takeshi Kiyoi

Aim: Molecular hydrogen is not only expected to be used as an energy-generating resource, but also to have preventive effects on a variety of clinical...

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