Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway

Boyan Liu, Geru Tao, Jie Jiang, Shucun Qin, Sijie Xing, Xiangyan Zhang, Ya'nan Zhao

Objective: Molecular hydrogen (H2) has been considered a potential therapeutic target in many cancers. Therefore, we sought to assess the potential effect of H2 on...

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Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent

Hikaru Kobayashi, Kazumasa Matsumoto-Miyai, Noriyoshi Usui, Shoichi Shimada, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura

Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the...

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Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Chen Ma, Fei Xie, Jin He, Meng Wang, Meng-Yu Liu, Peng-Xiang Zhao, Xue Jiang, Xue-Mei Ma, Yang Yi, Yao Mawulikplimi Adzavon, Zhi-Ming Xun, Zi-Jia Liu

The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have...

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Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth

Bo Liu, Fei Gong, Huali Lei, Liang Cheng, Nailin Yang, Xianwen Wang, Xiaoyuan Yang, Yu Chao, Yu Hao, Yuehan Gong, Zhuang Liu

Hydrogen can be used as an anti-cancer treatment. However, the continuous generation of H2 molecules within the tumor is challenging. Magnesium (Mg) and its alloys...

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Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in an asphyxial rat model of cardiac arrest

Jiali Wang, Jialin Guo, Jiaxin Li, Qiuhuan Yuan, Shujian Wei, Tonghui Xu, Xiangkai Zhao, Xiaohui Gong, Xinhui Fan, Xinxin Yin, Xuchen Han, Yuguo Chen

Hydrogen (H2) therapy is a therapeutic strategy using molecular H2. Due to its ability to regulate cell homeostasis, H2 therapy has exhibited marked therapeutic effects...

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Effect of Hydrogen Inhalation Therapy on Hearing Loss of Patients With Nasopharyngeal Carcinoma After Radiotherapy

Kecheng Xu, Tianyu Lu, Xiaofeng Kong, You-Yong Lu, Zhinan Yin

Objective: To evaluate the clinical efficacy and safety of hydrogen inhalation in improving hearing loss in patients with long-term survival of nasopharyngeal carcinoma after radiotherapy....

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A new therapy against ulcerative colitis via the intestine and brain using the Si-based agent

Hikaru Kobayashi, Hiroe Imai, Hiroto Yanagawa, Ikuei Hirota, Iwao Ohtsu, Shoichi Shimada, Takuya Sumi, Yoshichika Yoshioka, Yoshihisa Koyama, Yuanjie Sun, Yuki Kobayashi

Ulcerative colitis (UC) is a non-specific inflammatory bowel disease that causes ulcers and erosions in the colonic mucosa and becomes chronic with cycles of amelioration...

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Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men

Katsuhiro Koyama, Shohei Dobashi, Takaaki Arisawa, Tamotsu Fukuoka, Yudai Shibayama

Molecular hydrogen has been suggested to have a cytoprotective effect on the whole body and to enhance exercise performances. However, the effect of hydrogen-rich gas...

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UPLC/MS-Based Metabolomics Investigation of the Protective Effect of Hydrogen Gas Inhalation on Mice with Calcium Oxalate-Induced Renal Injury

Hongtao Lu, Jiarong Ding, Wei Chen, Wenrui Liu, Xuejun Sun, Zhiyong Guo, Zhongjiang Peng

Hydrogen has a significant protective effect on calcium oxalate-induced renal injury, but its effect on metabolic profiles is unknown. This study showed the effects of...

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Hydrogen Repairs LPS-Induced Endothelial Progenitor Cells Injury via PI3K/AKT/eNOS Pathway

Benhong Liu, Jielun Yu, Kaixuan Lv, Lichun Zhang, Lingyu Kong, Linlin Zhang, Nana Yang, Qingjie Mu, Shangmin Chu, Xiaopeng Jia, Yan Tian, Youzhen Wei

Endotoxins and other harmful substances may cause an increase in permeability in endothelial cells (ECs) monolayers, as well as ECs shrinkage and death to induce...

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Retracted: Hydrogen alleviates collagen-induced arthritis (CIA) in mice by inhibiting IL-22 levels

Hao Yang, Shuting Zhang, Weiping Fan, Xing Kang, Yan Tian, Yu Wang

Objective To investigate the therapeutic effect and mechanism of hydrogen (H2) on collagen-induced arthritis (CIA) in mice. Methods DBA/1 mice were randomly divided into normal...

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Hydrogen Gas Inhalation Regressed Coronary Artery Aneurysm in Kawasaki Disease-Case Report and Article Review

We studied the effect of molecular hydrogen H2 on the content of circulating endothelial cells and the macrohistological structure of the heart in rats with simulated chronic heart failure. Inhalation with 2% H2 was carried out repeatedly (40 min per ...

Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old and is among the most common acquired...

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