The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced diabetic rats

Budi Susatia, Ekowati Retnaningtyas, Siti Nur Arifah, Sri Rahayu Lestari

Background and aim: Water plays a pivotal role in the body. Alteration of the fluid balance promotes metabolic disorder, thus leading to the development of...

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Hydrogen attenuates endothelial glycocalyx damage associated with partial cardiopulmonary bypass in rats

Hiroki Iwata, Sang Kien Truong, Shingo Kawashima, Soichiro Mimuro, Takasumi Katoh, Tsunehisa Sato, Yoshiki Nakajima

Cardiopulmonary bypass (CPB) causes systemic inflammation and endothelial glycocalyx damage. Hydrogen has anti-oxidant and anti-inflammatory properties; therefore, we hypothesized that hydrogen would alleviate endothelial glycocalyx...

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Hydrogen-generating Si-based agent protects against skin flap ischemia-reperfusion injury in rats

Hikaru Kobayashi, Kazuya Kuroda, Koichi Tomita, Naoya Otani, Tateki Kubo, Yoshihisa Koyama, Yuki Kobayashi

Hydrogen is effective against ischemia-reperfusion (I/R) injury in skin flaps. However, the difficulty of continuously administering a sufficient amount of hydrogen using conventional methods has...

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PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression

Beibei Dong, Hongguang Chen, Huaying Lin, Qingqing Han, Xinyue Zhang, Yi Jiang, Yonghao Yu, Yuanyuan Bai

Sepsis-associated encephalopathy (SAE), a fatal complication of sepsis, contributes to cognitive impairment, high morbidity, and mortality. The molecular mechanism of hydrogen (H2) administration, as a...

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Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress

Chengchuang Zhan, Hongxiao Yang, Jiaren Liu, Jing Chi, Juncai Bai, Lihua Zhong, Shuang Liu, Wei Yang, Xinrui Yang, Yajing Lv, Yunan Gao

Cardiac hypertrophy occurs as a result of high levels of thyroid hormone, which may contribute to heart failure and is closely related to oxidative stress....

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FDG-PET/CT Assessment of the Cerebral Protective Effects of Hydrogen in Rabbits with Cardiac Arrest

Changshou She, Guoqing Huang, Hui Zhou, Shuo Hu, Xiangmin Li, Xiaoqin Lu, Xiaoye Mo, Yongxiang Tang, Zhengbin Yao

Background: Anatomical imaging methods and histological examinations have limited clinical value for early monitoring of brain function damage after cardiac arrest (CA) in vivo. Objective:...

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Protective Effects of Hydrogen-Rich Saline on Experimental Intestinal Volvulus in Rats

Cem Kaya, Cengiz Karakaya, Duygu Dayanir, Hayrunnisa Oral, Kaan Sonmez, Ramazan Karabulut, Zafer Turkyilmaz

Background: Intestinal volvulus can cause morbidity and mortality. Surgical reduction, on the other hand, could result in ischemia-reperfusion (I/R) injury. Hydrogen rich saline solution (HRSS...

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Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy

Bin Wang, Chaoqun Nie, Jiaren Liu, Juncai Bai, Mengshu Yu, Rentong Zou, Shuang Pan, Shuiqing Xi, Wei Yang, Xiaojian Hong

Hydrogen is a novel medical gas with several properties, including anti-oxidative, anti-inflammatory, anti-apoptotic, anti-allergic, and energy metabolism stimulating properties. Hydrogen therapy has been proven effective...

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Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway

Chengcheng Shen, Jianghe Zhang, Xiaoyue Lai, Xin Zhou, Yiming Zhang, Yujie Li

Wound healing is a complex dynamic process involving a large number of biological events. Excessive oxidative stress is a key factor delaying wound healing. Hydrogen...

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Magnesium Hydride Ameliorates Endotoxin-Induced Acute Respiratory Distress Syndrome by Inhibiting Inflammation, Oxidative Stress, and Cell Apoptosis

Di Feng, Hongtao Lu, Juan Wei, Lina Zhu, Meiyun Liu, Quanfu Li, Sheng Wang, Wanli Zhu, Xin Lv, Xuan Shi, Xuejun Sun, Yuanli Chen

Acute respiratory distress syndrome (ARDS) causes uncontrolled pulmonary inflammation, resulting in high morbidity and mortality in severe cases. Given the antioxidative effect of molecular hydrogen,...

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Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study

Dapeng Bao, Gengxin Dong, Jiahui Fu, Junhong Zhou

(1) Background: Exercise that exceeds the body's accustomed load can lead to oxidative stress and increased fatigue during intense training or competition, resulting in decreased...

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Development of a novel porcine ischemia/reperfusion model inducing different ischemia times in bilateral kidneys-effects of hydrogen gas inhalation

Eiji Kobayashi, Haruki Kume, Kohsuke Shirakawa, Motoaki Sano, Takashi Yokoo, Yoshitaka Kinoshita

Background: Acute kidney injury and its central pathology, renal ischemia reperfusion injury (IRI), have been studied in many animal models. Although renal IRI has been...

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