Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia

Hiroaki Kajiyama, Hiroyuki Tsuda, Kenji Imai, Mayo Miura, Rika Miki, Shima Hirako-Takamura, Shinya Toyokuni, Sho Tano, Takafumi Ushida, Tomoko Nakano-Kobayashi, Tomomi Kotani, Yoshinori Moriyama, Yukako Iitani, Yumiko Ito

Oxidative stress plays a pathological role in pulmonary hypoplasia and pulmonary hypertension in congenital diaphragmatic hernia (CDH). This study investigated the effect of molecular hydrogen...

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Hydrogen gas inhalation ameliorates cardiac remodelling and fibrosis by regulating NLRP3 inflammasome in myocardial infarction rats

A. Rong, Chaoqun Nie, Hongxiao Yang, Juncai Bai, Rentong Zou, Shuang Pan, Shuiqing Xi, Wei Yang, Xiaojian Hong, Xue Wang, Yunan Gao

It is noteworthy that prolonged cardiac structural changes and excessive fibrosis caused by myocardial infarction (MI) seriously interfere with the treatment of heart failure in...

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Hydrogen-Rich Water Alleviates the Nickel-Induced Toxic Responses (Inflammatory Responses, Oxidative Stress, DNA Damage) and Ameliorates Cocoon Production in Earthworm

Duried Alwazeer, Gizem Eser, Menekse Bulut, Mine Kokturk, Serkan Yildirim

In recent years, studies investigating the protective effect of hydrogen-rich water (HRW) against different diseases and the toxicity of some substances have attracted increasing attention....

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Hydrogen Attenuates Myocardial Injury in Rats by Regulating Oxidative Stress and NLRP3 Inflammasome Mediated Pyroptosis

Chaoqun Nie, Hongxiao Yang, Huijun Du, Shuang Liu, Wei Yang, Yajing Lv, Yunan Gao, Zi Hong

Purpose: Hydrogen (H2) is an antioxidant with anti-inflammatory and apoptosis functions.This study aimed to estimate the effects of H2 on acute myocardial infarction (AMI) in...

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Lung Inflation With Hydrogen During the Cold Ischemia Phase Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Pyroptosis in Rats

Bin Zheng, Entong Xing, Huacheng Zhou, Jiyu Kang, Panpan Zheng, Xueyao Wang

Background: Lung inflation with hydrogen is an effective method to protect donor lungs from lung ischemia-reperfusion injury (IRI). This study aimed to examine the effect...

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Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage

An Wu, Bingjie Jiang, Dandan Mao, Huayong Wu, Weimin Dai, Yunping Li

Purpose: Subarachnoid hemorrhage (SAH) is a common complication of cerebral vascular disease. Hydrogen has been reported to alleviate early brain injury (EBI) through oxidative stress...

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An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions

Jason Kharman, Michael L. McCullough, Tyler W. LeBaron

Traumatic brain injuries (TBIs) are a leading cause of death and disability. Sports-related TBIs are estimated to be more than several million per year. The...

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Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults

Alexis R. Cole, Francesca Sperotto, James A. DiNardo, John N. Kheir, Lynn A. Sleeper, Michael J. Rivkin, Stephanie Carlisle

Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and...

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Multifunctional Magnesium Anastomosis Staples for Wound Closure and Inhibition of Tumor Recurrence and Metastasis

Hao Wang, Hongzhou Peng, Jiahua Ni, Jie Lou, Jun Yan, Rui Zan, Shi Yang, Wenhui Wang, Xiaonong Zhang, Xinbao Kang, Yigang Chen, Yongping Zhou, Yu Sun

Biodegradable magnesium (Mg) implants spontaneously releasing therapeutic agents against tumors are an intriguing therapeutic approach for both tissue repair and tumor treatment. Anastomotic staples are...

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High concentration of hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice

Guolin Wang, Jiayan Zhang, Keliang Xie, Nan Zhao, Ruiqiang Sun, Yanchao Su, Yaoqi Wang, Yonghao Yu, Yuzun Wang, Zhen Wang

Background and aims: The lung is the first organ to fail in sepsis. Our previous studies have proven that 2% molecular hydrogen (H2) inhalation remain...

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The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial

Ana Ninic, Azra Guzonjic, Danijela Kojic, Darinka Korovljev, Dragana Zanini, Elvira Vukasinovic, Jelena Ostojic, Jelena Purac, Miron Sopic, Nikola Todorovic, Sanja Erceg, Sergej M. Ostojic, Srdjana Djordjievski, Valdemar Stajer

In this randomized controlled pilot trial, we investigated the effects of a 6-month intake of hydrogen-rich water (HRW) on several molecular and phenotypic biomarkers of...

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Attenuation of Myocardial Fibrosis Using Molecular Hydrogen by Inhibiting the TGF-β Signaling Pathway in Spontaneous Hypertensive Rats

Libo Liu, Qian Shi, Xiaohong Liu, Xiuchang Li, Yanmin Li

Background: Previous studies have shown that hydrogen (H2) can antagonize the fibrosis of various organs. We investigated whether hydrogen-rich saline (HRS) can attenuate myocardial fibrosis...

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