Hydrogen gas distribution in organs after inhalation: Real-time monitoring of tissue hydrogen concentration in rat

Junichi Sasaki, Koichiro Homma, Motoaki Sano, Ryo Yamanoto, Sayuri Suzuki

Hydrogen has therapeutic and preventive effects against various diseases. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains...

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Magnesium-based micromotors for enhanced active and synergistic hydrogen chemotherapy

Daniela A. Wilson, Fei Peng, Juanfeng Ou, Junbin Gao, Kun Liu, Lu Liu, Shuanghu Wang, Yicheng Ye, Yingfeng Tu, Yunrui Hu

Hydrogen therapy has recently emerged as an attractive approach for combating major diseases including cancer, diabetes, stroke and Parkinson's disease. Herein, we ingeniously fabricated a...

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Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy

Boyu Zhang, Changfeng Wu, Duyang Gao, Fei Wang, Hua Zhou, Xuanjun Zhang, Zhen Yuan

Semiconducting polymer dots (Pdots) have recently attracted considerable attention because of their photocatalytic activity as well as tunable optical band gap. In this contribution, we...

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Hydrogen‐Powered Microswimmers for Precise and Active Hydrogen Therapy Towards Acute Ischemic Stroke

Bin Chen, Cong Xu, Daniela A. Wilson, Fei Peng, Fei Wang, Jiamiao Jiang, Juanfeng Ou, Junbin Gao, Kun Liu, Quan Zhou, Shuanghu Wang, Shuwen Liu, Yicheng Ye, Yingfeng Tu, Zhen Wang

Biodegradable microswimmers offer great potential for minimally invasive targeted therapy due to their tiny scale, multifunctionality, and versatility. However, most of the reported systems focused...

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Porphyrin-Palladium Hydride MOF Nanoparticles for Tumor-Targeted Photoacoustic Imaging-Guided Hydrogenothermal Therapy of Cancer

Gaoxin Zhou, Han Zhang, Penghe Zhao, Qianjun He, Yanyuan Wen, Ying Shuai Wang, Zhaokui Jin

Hydrogen molecule as important energy gas recently was discovered to have high value in the treatment of many diseases, while the current constraint is low...

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Local generation of hydrogen for enhanced photothermal therapy

Danyang Chen, Jin Meng, Penghe Zhao, Qian Chen, Qianjun He, Tian Yang, Xifeng Lu, Zhaokui Jin, Zhen Gu

By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds...

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Supersaturated Hydrogen-Rich Water Hydrotherapy for Recovery of Acute Injury to the Proximal Phalanges on the 5th Toe: A Case Report

Antioxidants represent a powerful tool for many human diseases and, in particular, molecular hydrogen has unique characteristics that make it a very promising therapeutic agent against osteoporosis. Zebrafish scales offer an innovative model in which ...

Background: Traditional treatments of soft tissue injuries (STIs) and some musculoskeletal injuries (MSK-Is) involves therapies such as the RICE protocol, which consists of rest, ice,...

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Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass

A.P. Medvedev, A.V. Deryugina, D.A. Danilova, E.I. Nazarov, E.V. Taranov, G.V. Bolshukhin, M.V. Ryazanov, S.A. Fedorov, V.V. Pichugin, Yu.D. Brichkin

The aim of this work was to study the effect of molecular hydrogen on oxidative processes in cardiac surgery patients with acquired valve heart disease...

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Effects of hydrogen-rich water on attenuating fatigue induced by daily activities or mental tasks

N. Hiramatsu, O. Kajimoto, S. Tsuji, T. Monden, T. Watanabe

Objectives In 2007, the first report that hydrogen removes active oxygen was published, and many clinical and non-clinical studies have since been conducted using hydrogen...

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Hydrogen gas post-conditioning alleviates cognitive dysfunction and anxiety-like behavior in a rat model of subarachnoid hemorrhage

Hong-Yan Jia, Jing-Hua Song, Tian-Peng Shao, Yuan-Ping Zhao, Zhi-Bao Liu

Subarachnoid hemorrhage (SAH) results in high rates of mortality and lasting disability. Hydrogen gas (H2) is an antioxidant with demonstrated neuroprotective efficacy. The present study...

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Oral Hydrogen-Rich Water Alleviates Oxalate-Induced Kidney Injury by Suppressing Oxidative Stress, Inflammation, and Fibrosis

Hongtao Lu, Jianpeng Yu, Jiarong Ding, Jin Cheng, Lulu Liu, Qi Zhou, Tingting Zhao, Wei Chen, Xuejun Sun, Yachen Si, Zhiyong Gu

Objective: To explore the theraputic effects and potential mechanisms of hydrogen-rich water (HRW) against oxalate-induced kidney injury. Methods: The mouse model of Calcium oxalate (CaOx)...

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The Preventive Role of Hydrogen-Rich Water in Thioacetamide-Induced Cholangiofibrosis in Rat Assessed by Automated Histological Classification

Chaofu Li, Guanzhen Yu, Xiaoqiang Gu, Xing Zhao, Ying Chen

Background: Cholangiofibrosis is a controversial intrahepatic cholangial lesion that precedes the development of cholangiocarcinoma. Here, we demonstrate that molecular hydrogen (H2) can be used to...

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