Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players

Andrew McKune, Barbora Sladeckova, Deepesh Khanna, Iva Klimesova, Jakub Krejci, Michal Botek, Michal Valenta

Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is...

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Hydrogen–oxygen therapy can alleviate radiotherapy-induced hearing loss in patients with nasopharyngeal cancer

Duanming Du, Feng Mu, Jibing Chen, Kecheng Xu, Tianyu Lu, Xiaofeng Kong

Three patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12, 2, and 0.5 years after radiotherapy, respectively. The secretions subsided after conventional drug and...

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Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response

Hiroshi Nishiwaki, Jun-Ichi Takeda, Kinji Ohno, Koki Takeda, Masaki Teranishi, Mikako Ito, Satoru Hasegawa, Shuto Negishi, Tomoya Hasegawa, Tyler W. LeBaron

Molecular hydrogen ameliorates pathological states in a variety of human diseases, animal models, and cell models, but the effects of hydrogen on cancer have been...

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Micromotor-Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy

Fei Peng, Hanfeng Qin, Huaan Li, Jia Sun, Jiamiao Jiang, Junbin Gao, Kun Liu, Ruotian Zhang, Weichang Huang, Wenxin Xu, Yanzhen Song, Yicheng Ye, Yingfeng Tu, Yunrui Hu

Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single...

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Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model

Can Cheng, Chen Li, Fukuda Kohei, Guiqing Peng, Haihong Hao, Jing Ye, Yiran Cao

Since the anti-inflammatory effect of hydrogen has been widely known, it was supposed that hydrogen could suppress tissue damage by inhibiting virus-related inflammatory reactions. However,...

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The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Duried Alwazeer, Ebru Karadag Sari, Menekse Bulut, Mushap Kuru, Mustafa Makav, Sukran Yediel Aras

Research question: What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)? Design: Female rats were divided into four groups, each...

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Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19: A retrospective study of medical records

Dafeng Chen, Peng Luo, Qing He, Shian Huang, Wei Lei, Yuan He, Yuanfang Ding, Zufeng Huang

A global public health crisis caused by the 2019 novel coronavirus disease (COVID-19) leads to considerable morbidity and mortality, which bring great challenge to respiratory...

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The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa

Meizhu Chen, Qian Ye, Sheng Zhang, Weiming Yan, Xiaohong Chen, Xingchui Lin, Yanjian Chen, Yunpeng Wang

Objective: To investigate the feasibility and effectiveness of hydrogen in the treatment of retinitis pigmentosa (RP) patients through the drinking of hydrogen-rich water (HRW). Methods:...

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Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

Andrew McKune, Barbora Sladeckova, Dalibor Pastucha, Iva Klimesova, Jakub Krejci, Michal Botek, Michal Valenta, Petr Konecny

Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties....

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Inhibition of retinal ischemia-reperfusion injury in rats by inhalation of low-concentration hydrogen gas

Atsushi Hayashi, Kenichi Arai, Mitsuya Otsuka, Yoshiko Yoshida

Purpose: To investigate the inhibitory effect of hydrogen gas inhalation on retinal ischemia reperfusion (I/R) injury using a rat model. Methods: Six-week-old male Sprague-Dawley rats...

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Hydrogen inhalation promotes recovery of a patient in persistent vegetative state from intracerebral hemorrhage: A case report and literature review

Feng-Ming Xiao, Hai-Feng Wei, Jing Qiao, Wen-Jie Tang, Yan Huang, You-Zhen Wei, Yuan-Yun Xie

Background: Persistent vegetative state (PVS) is a devastating and long-lasting clinical condition with high morbidity and mortality; currently, there are no available effective interventions. Case...

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Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway

Cong-Cong Zhang, Guang Shi, Jing Wang, Rong Chen, Xiang-Jian Zhang, Yuan-Yuan Du

This study explored the protective effect and mechanism of hydrogen‑rich saline (HRS) on the neurological function of mice with cerebral ischemia. Effects of HRS on...

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