Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis

Changjun Wang, Hongzhi Yang, Jiaying Dai, Jiean Xu, Jinwen Xu, Luyao Xu, Wei Liu, Wen Su, Wenhai Guo, Xiaodong Zhang, Ya Cheng, Yaxing Zhang, Yun Chen

Alcoholic liver disease (ALD), which is induced by chronic heavy alcohol consumption, accompanies complicated pathological mechanisms, including oxidative stress, inflammation, cell death, epigenetic changes and...

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Itraq-Based Quantitative Proteomic Analysis of Lungs in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment

Chao Qin, Guolin Wang, Hongguang Chen, Keliang Xie, Yang Yu, Yingxue Bian, Yonghao Yu, Yuchang Xin

Sepsis-associated acute lung injury (ALI), which carries a high morbidity and mortality in patients, has no effective therapeutic strategies to date. Our group has already...

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Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports

Bunpei Sato, Fumitake Satoh, Shin-Ichi Hirano, Yoshiyasu Takefuji, Yusuke Ichikawa

No abstract available Publish Year 2024 Country Japan Rank Positive Journal Medical Gas Research Primary Topic Brain Secondary TopicChronic Fatigue Syndrome Model Human Tertiary TopicChronic...

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Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway

Jin Zhang, Xiuying Wu, Ze Zhang, Zhiling Fu

Background. Hydrogen-rich saline (HRS) has strong anti-inflammatory, antioxidative stress, and antiapoptotic properties. The study focused on the protection of HRS on lipopolysaccharide (LPS)-induced acute lung...

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Efficacy and Safety of Hydrogen Therapy in Patients with Early-Stage Interstitial Lung Disease: A Single-Center, Randomized, Parallel-Group Controlled Trial

Chang Tang, Chenggong Guan, Fanping Yang, Haiqing Gao, Jin Yang, Lanting Wang, Li Ma, Lin Tang, Qiaozhi Gu, Shan He, Shengan Chen, Xiaoqun Luo, Ying Zhao, Yu Xu, Zhen Zhang, Zihua Chen

Purpose: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy...

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The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced diabetic rats

Budi Susatia, Ekowati Retnaningtyas, Siti Nur Arifah, Sri Rahayu Lestari

Background and aim: Water plays a pivotal role in the body. Alteration of the fluid balance promotes metabolic disorder, thus leading to the development of...

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Hydrogen attenuates endothelial glycocalyx damage associated with partial cardiopulmonary bypass in rats

Hiroki Iwata, Sang Kien Truong, Shingo Kawashima, Soichiro Mimuro, Takasumi Katoh, Tsunehisa Sato, Yoshiki Nakajima

Cardiopulmonary bypass (CPB) causes systemic inflammation and endothelial glycocalyx damage. Hydrogen has anti-oxidant and anti-inflammatory properties; therefore, we hypothesized that hydrogen would alleviate endothelial glycocalyx...

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Hydrogen-generating Si-based agent protects against skin flap ischemia-reperfusion injury in rats

Hikaru Kobayashi, Kazuya Kuroda, Koichi Tomita, Naoya Otani, Tateki Kubo, Yoshihisa Koyama, Yuki Kobayashi

Hydrogen is effective against ischemia-reperfusion (I/R) injury in skin flaps. However, the difficulty of continuously administering a sufficient amount of hydrogen using conventional methods has...

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PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression

Beibei Dong, Hongguang Chen, Huaying Lin, Qingqing Han, Xinyue Zhang, Yi Jiang, Yonghao Yu, Yuanyuan Bai

Sepsis-associated encephalopathy (SAE), a fatal complication of sepsis, contributes to cognitive impairment, high morbidity, and mortality. The molecular mechanism of hydrogen (H2) administration, as a...

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Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress

Chengchuang Zhan, Hongxiao Yang, Jiaren Liu, Jing Chi, Juncai Bai, Lihua Zhong, Shuang Liu, Wei Yang, Xinrui Yang, Yajing Lv, Yunan Gao

Cardiac hypertrophy occurs as a result of high levels of thyroid hormone, which may contribute to heart failure and is closely related to oxidative stress....

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FDG-PET/CT Assessment of the Cerebral Protective Effects of Hydrogen in Rabbits with Cardiac Arrest

Changshou She, Guoqing Huang, Hui Zhou, Shuo Hu, Xiangmin Li, Xiaoqin Lu, Xiaoye Mo, Yongxiang Tang, Zhengbin Yao

Background: Anatomical imaging methods and histological examinations have limited clinical value for early monitoring of brain function damage after cardiac arrest (CA) in vivo. Objective:...

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Protective Effects of Hydrogen-Rich Saline on Experimental Intestinal Volvulus in Rats

Cem Kaya, Cengiz Karakaya, Duygu Dayanir, Hayrunnisa Oral, Kaan Sonmez, Ramazan Karabulut, Zafer Turkyilmaz

Background: Intestinal volvulus can cause morbidity and mortality. Surgical reduction, on the other hand, could result in ischemia-reperfusion (I/R) injury. Hydrogen rich saline solution (HRSS...

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