Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition

Hongguang Chen, Kuibin Xu, Ruichen Shu, Xiaobei Zhang, Xiaofeng Liu, Yonghao Yu, Yuan Li

Background: Pulmonary microvascular endothelial cells (PMVECs) are initial targets of sepsis-induced acute lung injury (ALI). During the apoptosis of PMVECs, tight junctions (TJ) and adherens...

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Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats

Huan Liu, Hui Yuan, Jianguo Li, Mengya Liu, Xiaoman Chen, Xiaoming Liu, Xiujun Qin, Yong Wang

Background: Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms...

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Effects of hydrogen on the lung damage of mice at early stage of severe burn

C. Qin, J.H. Zhang, T.T. Feng, Y.H. Yu, Y.X. Bian

Objective: To investigate the effects of hydrogen on the lung damage of mice at early stage of severe burn. Methods: One hundred and sixty ICR...

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Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study

Alex Tarnava, Ghizal Fatima, Jan Fedacko, Ram B. Singh, Tyler W. LeBaron, Viliam Mojto

Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and...

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The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial

Feng Sun, Hong Bao, Hui Chen, Jie-Ming Qu, Meng-Meng Shi, Qing-Yun Li, Rong Chen, Ting Cheng, Wei-Ning Xiong, Xiao-Dan Wang, Yuan-Lin Song, Yun-Feng Zhang, Yun-Tian Chen

Clinical studies had found that hydrogen/oxygen mixed inhalation was beneficial to ameliorate the respiratory symptoms in the adjuvant treatment of patients with COVID-19. We aimed...

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H2 Inhibits the Formation of Neutrophil Extracellular Traps

Eiji Kobayashi, Genki Ichihara, Hiroki Kitakata, Kazuhisa Sugai, Kohsuke Shirakawa, Motoaki Sano, Yoji Hakamata, Yoshinori Katsumata

Neutrophil extracellular traps (NETs) contribute to inflammatory pathogenesis in numerous conditions, including infectious and cardiovascular diseases, and have attracted attention as potential therapeutic targets. H2...

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Hydrogen prevents lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by inhibiting store-operated Ca2+ entry regulated by STIM1/Orai1

Guiyue Wang, Hongguang Chen, Ruichen Shu, Xuan Zhang, Yiqing Yin, Yuan Li

Background: Sepsis is a type of life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The lung is the most vulnerable...

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Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence

Jun Imai, Ryosuke Kurokawa, Shin-Ichi Hirano, Takahiro Sakai

Bacteria inhabiting the human gut metabolize microbiota-accessible carbohydrates (MAC) contained in plant fibers and subsequently release metabolic products. Gut bacteria produce hydrogen (H2), which scavenges...

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NIR-Activatable Heterostructured Nanoadjuvant Cop/Nicop Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy And Photoimmunotherapy

Bin Liu, binbin Ding, Chunzheng Yang, Jia Tan, Jiashi Zhang, Jun Lin, Meifang Wang, Meng Yuan, Mengyu Chang, Ping'an Ma, Yulong Bian, Zhendong Liu

Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic non-invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation...

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Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence

Hua Liu, Jing Xie, Li Zhang, Lihua Li, Ruichan Li, Xudong Huang, Yanli Liu

Hydrogen possesses antioxidative effects and cures numerous types of ophthalmopathy, but the mechanism of hydrogen on ROS-induced retinal senescence remains elusive. In this study, retinal...

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Fructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid decreases maternal and female fetal oxidative stress by increasing intestinal microbe-derived hydrogen gas

Akito Shimouchi, Asuka Okuda, Kenichi Tanabe, Sadako Nakamura, Toshiyuki Nakayama, Tsuneyuki Oku, Yuri Kintaka

Fructooligosaccharide (FOS) is fermented by intestinal microbes to generate intestinal microbe-derived hydrogen gas (IMDH). Oxidative stress increases during gestation, whereas hydrogen gas has antioxidant effects...

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Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways

Fei Xie, Jin He, Mengyu Liu, Pengxiang Zhao, Shiwen Ma, Xiaokang Zhang, Xue Jiang, Xuemei Ma, Yang Yi, Yao Mawulikplimi Adzavon

Molecular hydrogen (H2) has emerged as a new therapeutic option in several diseases and is widely adopted by healthy people. However, molecular data to support...

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