Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy

Bin Wang, Chaoqun Nie, Jiaren Liu, Juncai Bai, Mengshu Yu, Rentong Zou, Shuang Pan, Shuiqing Xi, Wei Yang, Xiaojian Hong

Hydrogen is a novel medical gas with several properties, including anti-oxidative, anti-inflammatory, anti-apoptotic, anti-allergic, and energy metabolism stimulating properties. Hydrogen therapy has been proven effective...

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Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway

Chengcheng Shen, Jianghe Zhang, Xiaoyue Lai, Xin Zhou, Yiming Zhang, Yujie Li

Wound healing is a complex dynamic process involving a large number of biological events. Excessive oxidative stress is a key factor delaying wound healing. Hydrogen...

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Magnesium Hydride Ameliorates Endotoxin-Induced Acute Respiratory Distress Syndrome by Inhibiting Inflammation, Oxidative Stress, and Cell Apoptosis

Di Feng, Hongtao Lu, Juan Wei, Lina Zhu, Meiyun Liu, Quanfu Li, Sheng Wang, Wanli Zhu, Xin Lv, Xuan Shi, Xuejun Sun, Yuanli Chen

Acute respiratory distress syndrome (ARDS) causes uncontrolled pulmonary inflammation, resulting in high morbidity and mortality in severe cases. Given the antioxidative effect of molecular hydrogen,...

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Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study

Dapeng Bao, Gengxin Dong, Jiahui Fu, Junhong Zhou

(1) Background: Exercise that exceeds the body's accustomed load can lead to oxidative stress and increased fatigue during intense training or competition, resulting in decreased...

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Development of a novel porcine ischemia/reperfusion model inducing different ischemia times in bilateral kidneys-effects of hydrogen gas inhalation

Eiji Kobayashi, Haruki Kume, Kohsuke Shirakawa, Motoaki Sano, Takashi Yokoo, Yoshitaka Kinoshita

Background: Acute kidney injury and its central pathology, renal ischemia reperfusion injury (IRI), have been studied in many animal models. Although renal IRI has been...

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Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway

Boyan Liu, Geru Tao, Jie Jiang, Shucun Qin, Sijie Xing, Xiangyan Zhang, Ya'nan Zhao

Objective: Molecular hydrogen (H2) has been considered a potential therapeutic target in many cancers. Therefore, we sought to assess the potential effect of H2 on...

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Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent

Hikaru Kobayashi, Kazumasa Matsumoto-Miyai, Noriyoshi Usui, Shoichi Shimada, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura

Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the...

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Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Chen Ma, Fei Xie, Jin He, Meng Wang, Meng-Yu Liu, Peng-Xiang Zhao, Xue Jiang, Xue-Mei Ma, Yang Yi, Yao Mawulikplimi Adzavon, Zhi-Ming Xun, Zi-Jia Liu

The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have...

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Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth

Bo Liu, Fei Gong, Huali Lei, Liang Cheng, Nailin Yang, Xianwen Wang, Xiaoyuan Yang, Yu Chao, Yu Hao, Yuehan Gong, Zhuang Liu

Hydrogen can be used as an anti-cancer treatment. However, the continuous generation of H2 molecules within the tumor is challenging. Magnesium (Mg) and its alloys...

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Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in an asphyxial rat model of cardiac arrest

Jiali Wang, Jialin Guo, Jiaxin Li, Qiuhuan Yuan, Shujian Wei, Tonghui Xu, Xiangkai Zhao, Xiaohui Gong, Xinhui Fan, Xinxin Yin, Xuchen Han, Yuguo Chen

Hydrogen (H2) therapy is a therapeutic strategy using molecular H2. Due to its ability to regulate cell homeostasis, H2 therapy has exhibited marked therapeutic effects...

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Effect of Hydrogen Inhalation Therapy on Hearing Loss of Patients With Nasopharyngeal Carcinoma After Radiotherapy

Kecheng Xu, Tianyu Lu, Xiaofeng Kong, You-Yong Lu, Zhinan Yin

Objective: To evaluate the clinical efficacy and safety of hydrogen inhalation in improving hearing loss in patients with long-term survival of nasopharyngeal carcinoma after radiotherapy....

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A new therapy against ulcerative colitis via the intestine and brain using the Si-based agent

Hikaru Kobayashi, Hiroe Imai, Hiroto Yanagawa, Ikuei Hirota, Iwao Ohtsu, Shoichi Shimada, Takuya Sumi, Yoshichika Yoshioka, Yoshihisa Koyama, Yuanjie Sun, Yuki Kobayashi

Ulcerative colitis (UC) is a non-specific inflammatory bowel disease that causes ulcers and erosions in the colonic mucosa and becomes chronic with cycles of amelioration...

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