Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB Inflammatory Pathway

Li-Ying Sun, Pei-Chen Lai, Qiang Wan, Ting-Ting Li, Wan-Chao Yang, Wen-Zhi Li, Xin Zhang, Yu-Rong Zhang

Diabetes is an independent risk factor for stroke and amplifies inflammation. Diabetic stroke is associated with a higher risk of death and worse neural function....

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The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial

Kai Fan, Ling Jin, Qin Ge, Shangxi Liu, Shaoqing Yu, Shiwang Tan, Yang Wang, Zisheng Ai

Purpose: Chronic rhinitis (CR) is a common chronic inflammation of the nasal mucosa. Nasal saline irrigation has been demonstrated to be an effective treatment for...

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Abstract: Effect of hydrogen therapy on the proteomic profile of exhaled breath condensate after recovery from COVID-19

Alexander Brzhozovskiy, Alexander Chuchalin, Alexey Kononikhin, Anna Kozyr, Anna Ryabokon, Eugene Nikolaev, Ludmila Shogenova, Maria Indeykina, Natalia Zakharova, Sergey Varfolomeev

Exhaled breath condensate (EBC) is a promising object for biomarkers search as it contains compounds reflecting changes of biological processes caused by various respiratory diseases...

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Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound Healing by Activating Antioxidant Activity in a Rat Alkali Burn Model

Akira Shimizu, Hiroshi Takahashi, Masaaki Uchiyama, Momoko Kasamatsu, Takeshi Arima, Toyo Ikebukuro, Yuji Nakano, Yutaro Tobita

Many studies have demonstrated the therapeutic effects of hydrogen in pathological conditions such as inflammation; however, little is known about its prophylactic effects. The purpose...

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Enhanced Removal of Free Radicals by Aqueous Hydrogen Nanobubbles and Their Role in Oxidative Stress

Shu Liu, Wen-Xiong Wang, Wenhong Fan, Xiaomin Li, You Zhang

Elevated levels of reactive oxygen radicals caused by environmental stress are the key triggers of inflammation, aging, and disease; thus, it is critical to develop...

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Synergistic Effect of Hydrogen and 5-Aza on Myogenic Differentiation through the p38 MAPK Signaling Pathway in Adipose-Derived Mesenchymal Stem Cells

Bin Xie, Erkai Pang, Jihang Dai, Jingcheng Wang, Lei Hou, Mingsheng Liu, Wenyong Fei, Xuanqi Wang

Background and objectives: This study aims to clarify the systems underlying regulation and regulatory roles of hydrogen combined with 5-Aza in the myogenic differentiation of...

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The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic Adjustments during High-Intensity Intermittent Exercise in Humans

Ahad Abdulkarim D. Alharbi, Naoyuki Ebine, Noriaki Iwamoto, Satoshi Nakae, Tatsuya Hojo, Yoshiyuki Fukuoka

This research examined the effects of single-dose molecular hydrogen (H2) supplements on acid-base status and local muscle deoxygenation during rest, high-intensity intermittent training (HIIT) performance,...

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Antioxidation activity of molecular hydrogen via protoheme catalysis in vivo: an insight from ab initio calculations

Chol-Jun Yu, Myong-Su Kang, Song-Ae Kim, Yu-Chol Jong

Recently, molecular hydrogen has been found to exhibit antioxidation activity through many clinical experiments, but the mechanism has not been fully understandable at atomic level....

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Molecular Hydrogen Reduces Electromagnetic Pulse-Induced Male Rat Reproductive System Damage in a Rodent Model

Fu Gao, Hong-Li Yan, Hui Du, Jia-Ming Guo, Li-Na Qin, Long Ma, Lu-Cheng Cao, Ming-Hua Liu, Neng-Zhuang Wang, Wei Hao, Wen-Bo Feng, Yao Wang

Infertility has got to be a broadly concerned social issue these days, in which the malefactor cannot be overlooked. Numerous studies have shown that electromagnetic...

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Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen

A.A. Skokova, A.P. Medvedev, A.V. Deryugina, D.A. Danilova, M.V. Ryazanov, S.A. Fedorov, V.V. Pichugin, Yu.D. Brichkin

We studied the effect of molecular hydrogen (H2) on the content of 2,3-diphosphoglyceric acid (2,3-DPG), ATP, malondialdehyde, and catalase activity in erythrocytes in chronic heart...

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Accurate in vivo real-time determination of the hydrogen concentration in different tissues of mice after hydrogen inhalation

Boyan Liu, Dan Wang, Huirong Sun, Jingjie Zhong, Junli Xue, Qianqian Gu, Shucun Qin, Wenjun Zhu, Yanhong Si, Yi Lu

As an antioxidant, anti-inflammatory and anti-apoptotic agent, hydrogen (H2) shows a promising potential in basic and clinical research against various diseases owing to its safety...

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Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats

Dan-Feng Fan, Hui-Jun Hu, Qiang Sun, Xiao-Chen Han, Zhou-Heng Ye

Diabetic peripheral neuropathy (DPN) is a complex disorder caused by long-standing diabetes. Oxidative stress was considered the critical creed in this DPN pathophysiology. Hydrogen has...

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