Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study

Aleksandr Pavlovich Medvedev, Anna Vaycheslavovna Deryugina, Darya Andreevna Danilova, Evgenii Ivanovich Nazarov, Evgenii Vladimirovich Taranov, Evgenii Vladomirovich Makarov, Michail Valerevich Riazanov, Sergey Andreevich Fedorov, Vladimir Viktorovich Pichugin, Yurevich Smorkalov Andrej, Yurii Dmitrievich Brichkin

Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular...

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Effect of hydrogen intervention on refractory wounds after radiotherapy: A case report

Meng-Yu Liu, Ming-Zi Zhang, Peng-Xiang Zhao, Rui-Liu Luo, Xiao-Hu Wen, Xu-Juan Zhang, Xue-Mei Ma, Yao Mawulikplimi Advazon, You-Bin Wang, Zheng Dang, Zi-Yi Liu

Background: Patients with keloids who receive radiotherapy (RT) after surgery can develop refractory wounds that cannot be healed by the patient's own repair system. Such...

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Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3

Dongchang Wang, Gang Chen, Lifei Wang, Yu Zhang, Zhenfeng Yan

Objective: Lung cancer is currently the cancer with the highest incidence and death toll worldwide. Hydrogen gas has been found to affect a variety of...

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Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and necroptosis in a rat model of glycerol-induced acute kidney injury

Bo-Yan Liu, Jun-Li Xue, Meng-Yu Zhang, Min Zhao, Ming-Yue Wang, Qian-Qian Gu, Shu-Cun Qin, Xiao-Yi Zhang

Acute kidney injury (AKI) is the major complication of rhabdomyolysis (RM) clinically, which is usually mimicked by glycerol injection in basic research. Oxidative stress, inflammatory...

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Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria

Er-Kai Pang, Lei Hou, Ming-Sheng Liu, Rang-Shan Gao, Wen-Yong Fei, Yang-Yang Hu, Yu-Cheng Zhang, Yu-Xia Yang

Background: Acute skeletal muscle injuries are common physical or sports traumas. Cellular therapy has excellent potential for regeneration after skeletal muscle injury. Adipose-derived stem cells...

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Hydrogen saline water accelerates fracture healing by suppressing autophagy in ovariectomized rats

Jialiang Guo, Siyu Tian, Weichong Dong, Xiaojuan Zhang, Yingze Zhang, Yuchuan Wang, Zhiyong Hou, Zhongzheng Wang

Objective: The treatment of osteoporotic fractures is difficult, and to minimize the negative result or poor functional rehabilitation, this study focuses on hydrogen water (HRW)...

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Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells

Chieko Aoki, Daisuke Sugiyama, Hiroaki Kajiyama, Hiroyoshi Nishikawa, Kenji Imai, Noriyuki Nakamura, Rika Miki, Shinya Toyokuni, Takefumi Ushida, Taro Owaki, Teruyuki Mizutani, Tomoko Kobayashi, Tomomi Kotani, Yoshihiro Koya, Yukako Iitani

Aims: Molecular hydrogen (H2) has attracted growing interest because of its implications in various diseases. However, the molecular mechanisms underlying the remarkable effect of a...

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Hydrogen-Rich Water as a Novel Therapeutic Strategy for the Affective Disorders Linked with Chronic Neuropathic Pain in Mice

Gerard Batalle, Ignacio Martinez-Martel, Maria Martinez-Serrat, Olga Pol, Santiago Coral-Perez, Xue Bai

Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with...

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Hydrogen Intake Relieves Alcohol Consumption and Hangover Symptoms in Healthy Adults: a Randomized and Placebo-Controlled Crossover Study

Aihua Zhang, Guohua Song, Guoyong Ding, Xiang Lv, Xiao Li, Xinxin Xu, Yuanfeng Lu

Background: Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socio-economic burden. Objectives: The aim of this study was to investigate the...

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Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A Preliminary Report

Aleksandra M. Rogowska, Binnaz Asanova, Danuta Nowicka, Karolina Chilicka, Monika Rusztowicz, Renata Szygula

Acne and skin lesions that appear in its course deteriorate the quality of life of patients, cause depression and the emergence of suicidal thoughts. Cosmetic...

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Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice

Christie R.A. Leite-Panissi, Gerard Batalle, Ignacio Martinez-Martel, Maria Martinez-Serrat, Olga Pol, Santiago Coral-Perez, Xue Bai

Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H2) as a new therapy for neurological disorders has been demonstrated....

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Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in mice

Hongling Yin, Shaolin Ma, Yajing Feng, Yi Duan, Youzhen Wei, Zhongliang Guo

Background: Chronic inflammation and oxidant/antioxidant imbalance are two main pathological features associated with lipopolysaccharide (LPS)-induced acute lung injury (ALI). The following study investigated the protective...

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