Influence of oxygen concentration on the neuroprotective effect of hydrogen inhalation in a rat model of cardiac arrest

Bihua Chen, Changlin Yin, Jianjie Wang, Jingru Li, Yiming Shen, Yongqin Li

Background: Post-cardiac arrest (CA) brain injury is the main cause of death in patients resuscitated from CA. Previous studies demonstrated that hydrogen inhalation mitigates post-CA...

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Electrolyzed Hydrogen Water Alleviates Abdominal Pain through Suppression of Colonic Tissue Inflammation in a Rat Model of Inflammatory Bowel Disease

Di Hu, Mika Shigeta, Shigeru Kabayama, Tianliang Huang, Yasuyoshi Watanabe, Yilong Cui, Yuta Ochi

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the digestive tract and is typically accompanied by characteristic symptoms, such as abdominal pain, diarrhea,...

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Hydrogen effect on the mechanisms of mucosal immunity in patients with COVID-19

A.B. Vinnitskaya, A.G. Chuchalin, A.V. Poddubikov, I.A. Baranova, L.V. Shogenova, M.P. Kostinov, N.D. Abramova, N.O. Kryukova, O.A. Svitich, V.V. Zakharova

Aim: To study the inhalation of an active form of hydrogen effect to mucosal and system immunity in a rehabilitation program for health workers. Materials...

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The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial

Boyan Liu, Jiashuo Zhang, Shucun Qin, Xiubin Jia, Xue Jiang, Yazhuo Xue, Yunbo Xie

Objective: To explore the effect of a low-dose hydrogen-oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension. Methods: This randomized, placebo-controlled trial included 60 participants...

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Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia

Lili Guo, Ming Liu, Tao Duan

Background: Hypertensive disorders complicating pregnancy (HDCP) are one of the most serious medical disorders during pregnancy. Objectives: To investigate the effects of hydrogen on the...

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NIR-photocatalytic regulation of arthritic synovial microenvironment

Bin Zhao, Danyang Chen, Guanglin Li, Lingting Zeng, Qianjun He, Songqing Xie, Wei Tang, Zhaokui Jin

Synovial microenvironment (SME) plays a vital role in the formation of synovial pannus and the induction of cartilage destruction in arthritis. In this work, a...

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Hydrogen-Rich Water Mitigates LPS-Induced Chronic Intestinal Inflammatory Response in Rats via Nrf-2 and NF-κB Signaling Pathways

Jiantao Zhang, Jin Peng, Qi He, Shuaichen Li, Tao Liu

Long-term exposure to low-dose lipopolysaccharide can impair intestinal barriers, causing intestinal inflammation and leading to systemic inflammation. Hydrogen-rich water possesses antioxidant and anti-inflammatory functions and...

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Silicon nanoparticles for oral administration of molecular hydrogen

Hennie Marie Johnsen, Jo Klaveness, Marianne Hiorth, Werner Filtvedt

Medical use of hydrogen gas (H2) has been given increasing attention over the past 15 years with numerous clinical trials for a variety of indications....

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Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids

Akinori Mizoguchi, Akinori Wada, Chie Kurihara, Fumie Takei, Kazuki Horiuchi, Kazuyuki Narimatsu, Kengo Tomita, Kenichi Inaba, Masaaki Higashiyama, Masayuki Saruta, Nao Sugihara, Rina Tanemoto, Ryota Hokari, Shin Nishii, Shunsuke Komoto, Suguru Ito, Yasushi Satoh, Yoshihiro Akita, Yoshikiyo Okada, Yoshinori Hanawa

Background: Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy, the mechanism of which is involved in oxidative stress, can be lethal due to hemorrhage. Thus, we aimed to...

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Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with mental disorder

Bin Cong, Bing Xie, Chunling Ma, Di Wen, Meiqi Zhou, Mengmeng Wang, Wenbo Li, Xintao Wang, Yong Wang, Yun Lu

Methamphetamine (METH) is a potent and highly addictive psychostimulant and one of the most widely used illicit drugs, the abuse of which has become a...

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A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss

Eriko Nishihara, Hideo Ogawa, Hiroyuki Yamada, Jun Hyodo, Masahiro Okada, Masato Teraoka, Naohito Hato, Nobumitsu Honda, Shin-Ichi Hirano, Tadashi Yoshida, Takashi Fujiwara, Taro Takagi, Yusuke Shinomori

Background: Hydrogen (H2) has been reported to be effective in reducing hearing loss due to several causes in animal studies. However, no study has examined...

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Hydrogen improves exercise endurance in rats by promoting mitochondrial biogenesis

Bo Wen, Chao Li, Gaihong An, Jing Wang, Junyu Lu, Mingzhu Luo, Rong Fan, Wenbin Chu, Xiangchen Dang, Xuewei Chen, Yujiao Zhang

Background: Previous studies have shown that hydrogen water has antioxidant and anti-inflammatory effects on exercise-induced fatigue; however, its molecular mechanism remains unclar. Methods: Adult male...

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