The effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive pulmonary disease-like changes in an animal model

Chian-Yi Liu, Frank Lennox Douglas, Hsiu-Ming Saunders, Hui-Ju Yang, Kuang-Yih Wang, Min-Chung Shen, Wen-Hsin Tsou

Background: Molecular hydrogen, with its antioxidant and anti-inflammatory properties, may be suitable for the prevention and treatment of chronic obstructive pulmonary disease (COPD). This study...

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Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study

Mitsuharu Matsumoto, Nobuhiko Eda, Nobuhiro Nakamura, Ryota Sone, Saki Tsuno, Takao Akama

This study aimed to examine the effects of hydrogen gas (H2) produced by intestinal microbiota on participant conditioning to prevent intense exercise-induced damage. In this...

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Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy

Jiang Du, John Sieh Dumbuya, Lili Liang, Qiyi Zeng, Siqi Li, Yanchen Chen

Background: Sepsis-associated encephalopathy (SAE) is one of the most common types of sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is associated...

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Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota

Beibei Dong, Chunjing Zhou, Hongguang Chen, Ning Luo, Qingqing Han, Yingning Li, Yongbao Yu, Yuanyuan Bai

Introduction: In our experiments, male wild-type mice were randomly divided into four groups: the sham, SAE, SAE + 2% hydrogen gas inhalation (H2 ), and...

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Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults

Emi Yamano, Junzo Nojima, Kanako Tajima, Kei Mizuno, Kyoko Ebisu, Kyosuke Watanabe, Shigeru Kabayama, Yasuyoshi Watanabe, Yusuke Ohsaki

Chronic oxidative stress induces deterioration of health and a risk for the onset of various diseases. Previous clinical studies revealed that electrolyzed hydrogen water (EHW)...

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Synergistic Effects of Regular Walking and Alkaline Electrolyzed Water on Decreasing Inflammation and Oxidative Stress, and Increasing Quality of Life in Individuals with Type 2 Diabetes: A Community Based Randomized Controlled Trial

Adi Lukas Kurniawan, Ching Wen Chang, Christopher James Gordon, Hsiu Ting Tsai, Yohanes Andy Rias

Alkaline electrolyzed water (AEW) and walking are strongly recommended for ameliorating oxidative stress and inflammation. Nevertheless, there is a lack of information on the combination...

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Systemic and local effects of long-term exposure to alkaline drinking water in rats

K.J. Syrjanen, M.E. Merne, S.M. Syrjanen

Alkaline conditions in the oral cavity may be caused by a variety of stimuli, including tobacco products, antacids, alkaline drinking water or bicarbonate toothpaste. The...

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Alkaline Reduced Water Attenuates Oxidative Stress-Induced Mitochondrial Dysfunction and Innate Immune Response Triggered by Intestinal Epithelial Dysfunction

Ailyn Fadriquela, Cheol-Su Kim, Jayson M. Antonio, Soo-Ki Kim, Yun Ju Jeong

Redox imbalance in intestinal epithelial cells is critical in the early phases of intestinal injury. Dysfunction of the intestinal barrier can result in immunological imbalance...

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Hydroxyl-radical scavenging activity of hydrogen does not significantly contribute to its biological function

Fei Xie, Pengxiang Zhao, Qinjian Li, Xiaokang Zhang, Xin Zhang, Xuemei Ma, Xujuan Zhang, Yang Yi

Since Ohsawa et al. reported a biological antioxidant function of hydrogen in 2007, researchers have now shown it to exert protective effects in a wide...

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The Effects of Alkaline Reduced Water Administration to the Fasting Blood Glucose Levels in Patients with Type 2 Diabetes Mellitus

Dina Hisan Nabyla, Satrio Adi Wicaksono, Sulistiyati Bayu Utami

Background: Alkaline reduced water (ARW) is an electrolyzed water with pH>7. It showed an antioxidant and an antidiabetic benefit, but the results still vary. Aim:...

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Effects of Alkaline-Reduced Water on Exercise-Induced Oxidative Stress and Fatigue in Young Male Healthy Adults

Ailyn Fadriquela, Cheol-Su Kim, Hong-Young Jang, Il-Young Cho, Jayson M. Antonio, Ka-Eun Kim, Kyu-Jae Lee, Mihyun Lee, Wan-Sik An

Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field...

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ROS-responsive magnesium-containing microspheres for antioxidative treatment of intervertebral disc degeneration

Chunsheng Xiao, Jingguo Xin, Ruhui Li, Shaokun Zhang, Tianui Zhang, Xingmin Zhang, Yongjie Wang, Zhi Zheng

Intervertebral disc degeneration (IVDD) is a degenerative disease characterized by lower-back pain, causing disability globally. Antioxidant therapy is currently considered one of the most promising...

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