Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism

Harumi Ichimiya, Katsuya Iuchi, Naomi Kamimura, Shigeo Ohta

We previously reported that molecular hydrogen (H2) acts as a novel antioxidant to exhibit multiple functions. Moreover, long-term drinking of H2-water (water infused with H2)...

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The Effects of Alkaline Ionized Water Administration to the Total Cholesterol Levels in Patients with Type 2 Diabetes Mellitus Accompanied by Dyslipidemia

A. Ramadhan, S.A. Wicaksono, S.B. Utami, T.E. Nugroho

Background: Total cholesterol is a measure of the total amount of cholesterol components including LDL (low-density lipoprotein), HDL (high-density lipoprotein), and VLDL (very low-density lipoprotein)....

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Enzyme-Triggered Size-Switchable Nanosystem for Deep Tumor Penetration and Hydrogen Therapy

Anqiang Pan, Fangfang Zhou, Hui Xu, Shuquan Liang, Songwen Tan, Xiangjie Tian, Xingyu Fan, Xiyu Gong, Yongju He

The poor penetration of nanocarriers within tumor dense extracellular matrices (ECM) greatly restricts the access of anticancer drugs to the deep tumor cells, resulting in...

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Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion

Junichi Sasaki, Koichiro Homma, Ryo Yamamoto, Sayuri Suzuki, Shintaro Yamaguchi, Tomohisa Sujino

Background: Patients with mesenteric ischemia frequently suffer from bowel necrosis even after revascularization. Hydrogen gas has showed promising effects for ischemia-reperfusion injury by reducing reactive...

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Injectable spontaneous hydrogen-releasing hydrogel for long-lasting alleviation of osteoarthritis

Ben Liu, Cairong Li, Cuishan Huang, Di Chen, Feifei Zhou, Huan Yu, Ling Qin, Lingting Zeng, Long Li, Qianjun He, Wei Zhang, Wenjing Zhang, Yangyi Nie, Yuantao Zhang, Yuxiao Lai, Zhenyu Yao, Ziheng He

Excessive production of reactive oxygen species (ROS) amplifies pro-inflammatory pathways and exacerbates immune responses, and is a key factor in the progression of osteoarthritis (OA)....

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Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils

Eiji Kobayashi, Kazuhisa Sugai, Masahiko Fujisawa, Momoko Hirano, Motoaki Sano, Yoji Hakamata, Yoshinori Katsumata

Intraperitoneal administration of hydrogen (H2)-containing saline inhibited neuronal cell death in ischemic stroke in a number of animal models, but it is unknown whether H2...

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Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation

Michael Ivanovich Sheremet, Oksana Volodimirvna Kolesnik, Volf Yakovich Tsitrin, Vyacheslav Vasilievich Bilookiy, Yurii Yevgenivich Rohovyi

Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by...

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Hydrogen-Rich Saline Attenuates Chronic Allodynia after Bone Fractures via Reducing Spinal CXCL1/CXCR2-Mediated Iron Accumulation in Mice

Cuicui Liu, Lili Jiang, Pei Wang, Pingping Wang, Wei Chen, Yanting Wang

Purpose: Neuroinflammation often initiates iron overload in the pathogenesis of neurological disorders. Chemokine-driven neuroinflammation is required for central sensitization and chronic allodynia following fractures, but...

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Taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse

Akinori Kashio, Chikako Yamada, Kazuo Yasuhara, Shinichi Someya, Tatsuya Yamasoba, Teru Kamogashira

Mitochondrial dysfunction has been implicated in numerous common diseases as well as aging and plays an important role in the pathogenesis of sensorineural hearing loss...

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Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study

Andrew McKune, Barbora Sladeckova, Filip Neuls, Iva Klimesova, Jakub Krejci, Michal Botek, Michal Valenta, Robert Bajgar

Purpose: This study investigated the effects of acute, pre-exercise, hydrogen rich water (HRW) ingestion on running time to exhaustion at maximal aerobic speed in trained...

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Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation

Bo Qi, Chen Chen, Huayi Lin, Jing Liang, Keliang Xie, Lina Zhao, Shuqi Meng, Wanjie Ma, Xiaoli Zhuang, Yan Cui, Yu Song

Background: Sepsis-associated encephalopathy (SAE) is a cognitive dysfunction caused by sepsis. Hyperphosphorylated tau is considered to play a significant role in the progression of neurodegenerative...

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Solubility of inert gases in dog blood and skeletal muscle

J. Piiper, M. Meyer, U. Tebbe

Solubility of H2, Ar, CH4 and SF6 was determined at 310 K (37 degrees C) in water, in saline (0.154 mol NaCl/l H2O), in plasma...

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