RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-κB pathways

Jun-Song Chen, Wei Bao, Xiao-Wei Xi, Ye Yang, Yin-Ping Liu

Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in...

Read Study Article coming soon

Hydrogen-rich and hyperoxygenate saline inhibits lipopolysaccharide-induced lung injury through mediating NF-κB/NLRP3 signaling pathway in C57BL/6 mice

Hao Xu, Jian Wang, Jiankang Liu, Ke Cao, Yingying Fan, Zhihui Feng

Background: Background: Acute lung injury (ALI) is one kind of frequently occurred emergency in Intensive Care Unite with a high mortality. The underlying causes are...

Read Study Article coming soon

Investigating the Effect of Hydrogen-Rich Water on Liver Cell Injury and Liver Cancer by Regulating GP73/ TGF-β Pathway

Jingwen Zhang, Luhao Chen, Shuai Jiang, Wanbin Chen, Xunbo Hou, Yan Liu, Yi Yang, Ying Xing, Yingwen Hou, Yuanren Gao

Background Liver cancer is an extremely heterogeneous malignant disease among tumors identified to date. In recent years, a large number of studies have found that...

Read Study Article coming soon

Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model

Alex Tarnava, Asma Mostafapour, Fereshteh Asgharzadeh, Majid Khazaei, Tyler W. LeBaron

Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical...

Read Study Article coming soon

Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure

A.V. Deryugina, D.A. Danilova

We studied the effect of molecular hydrogen H2 on the content of circulating endothelial cells and the macrohistological structure of the heart in rats with...

Read Study Article coming soon

Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats

Daigoro Sasaki, Hiroyuki Matsuo, Ken-Ichi Matsumoto, Kohei Kawakami, Masato Nomura, Takaya Yamada

Hydrogen-rich water (HW) has been suggested to possess antioxidant properties of value in treatments of lifestyle diseases and for prevention of latent pathologies. To date,...

Read Study Article coming soon

Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model

Alex Tarnava, Amir Avan, Ghazaleh Khalili-Tanha, Mahdieh Darroudi, Majid Khazaei, Nima Khalili-Tanha, Seyedeh Elnaz Nazari, Tyler W. LeBaron

Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle...

Read Study Article coming soon

Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players

Andrew McKune, Barbora Sladeckova, Deepesh Khanna, Iva Klimesova, Jakub Krejci, Michal Botek, Michal Valenta

Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is...

Read Study Article coming soon

Hydrogen–oxygen therapy can alleviate radiotherapy-induced hearing loss in patients with nasopharyngeal cancer

Duanming Du, Feng Mu, Jibing Chen, Kecheng Xu, Tianyu Lu, Xiaofeng Kong

Three patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12, 2, and 0.5 years after radiotherapy, respectively. The secretions subsided after conventional drug and...

Read Study Article coming soon

Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response

Hiroshi Nishiwaki, Jun-Ichi Takeda, Kinji Ohno, Koki Takeda, Masaki Teranishi, Mikako Ito, Satoru Hasegawa, Shuto Negishi, Tomoya Hasegawa, Tyler W. LeBaron

Molecular hydrogen ameliorates pathological states in a variety of human diseases, animal models, and cell models, but the effects of hydrogen on cancer have been...

Read Study Article coming soon

Micromotor-Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy

Fei Peng, Hanfeng Qin, Huaan Li, Jia Sun, Jiamiao Jiang, Junbin Gao, Kun Liu, Ruotian Zhang, Weichang Huang, Wenxin Xu, Yanzhen Song, Yicheng Ye, Yingfeng Tu, Yunrui Hu

Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single...

Read Study Article coming soon

Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model

Can Cheng, Chen Li, Fukuda Kohei, Guiqing Peng, Haihong Hao, Jing Ye, Yiran Cao

Since the anti-inflammatory effect of hydrogen has been widely known, it was supposed that hydrogen could suppress tissue damage by inhibiting virus-related inflammatory reactions. However,...

Read Study Article coming soon