H2 Inhibits the Formation of Neutrophil Extracellular Traps

Eiji Kobayashi, Genki Ichihara, Hiroki Kitakata, Kazuhisa Sugai, Kohsuke Shirakawa, Motoaki Sano, Yoji Hakamata, Yoshinori Katsumata

Neutrophil extracellular traps (NETs) contribute to inflammatory pathogenesis in numerous conditions, including infectious and cardiovascular diseases, and have attracted attention as potential therapeutic targets. H2...

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Hydrogen prevents lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by inhibiting store-operated Ca2+ entry regulated by STIM1/Orai1

Guiyue Wang, Hongguang Chen, Ruichen Shu, Xuan Zhang, Yiqing Yin, Yuan Li

Background: Sepsis is a type of life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The lung is the most vulnerable...

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Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence

Jun Imai, Ryosuke Kurokawa, Shin-Ichi Hirano, Takahiro Sakai

Bacteria inhabiting the human gut metabolize microbiota-accessible carbohydrates (MAC) contained in plant fibers and subsequently release metabolic products. Gut bacteria produce hydrogen (H2), which scavenges...

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NIR-Activatable Heterostructured Nanoadjuvant Cop/Nicop Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy And Photoimmunotherapy

Bin Liu, binbin Ding, Chunzheng Yang, Jia Tan, Jiashi Zhang, Jun Lin, Meifang Wang, Meng Yuan, Mengyu Chang, Ping'an Ma, Yulong Bian, Zhendong Liu

Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic non-invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation...

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Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence

Hua Liu, Jing Xie, Li Zhang, Lihua Li, Ruichan Li, Xudong Huang, Yanli Liu

Hydrogen possesses antioxidative effects and cures numerous types of ophthalmopathy, but the mechanism of hydrogen on ROS-induced retinal senescence remains elusive. In this study, retinal...

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Fructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid decreases maternal and female fetal oxidative stress by increasing intestinal microbe-derived hydrogen gas

Akito Shimouchi, Asuka Okuda, Kenichi Tanabe, Sadako Nakamura, Toshiyuki Nakayama, Tsuneyuki Oku, Yuri Kintaka

Fructooligosaccharide (FOS) is fermented by intestinal microbes to generate intestinal microbe-derived hydrogen gas (IMDH). Oxidative stress increases during gestation, whereas hydrogen gas has antioxidant effects...

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Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways

Fei Xie, Jin He, Mengyu Liu, Pengxiang Zhao, Shiwen Ma, Xiaokang Zhang, Xue Jiang, Xuemei Ma, Yang Yi, Yao Mawulikplimi Adzavon

Molecular hydrogen (H2) has emerged as a new therapeutic option in several diseases and is widely adopted by healthy people. However, molecular data to support...

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Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis

Changjun Wang, Hongzhi Yang, Jiaying Dai, Jiean Xu, Jinwen Xu, Luyao Xu, Wei Liu, Wen Su, Wenhai Guo, Xiaodong Zhang, Ya Cheng, Yaxing Zhang, Yun Chen

Alcoholic liver disease (ALD), which is induced by chronic heavy alcohol consumption, accompanies complicated pathological mechanisms, including oxidative stress, inflammation, cell death, epigenetic changes and...

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Itraq-Based Quantitative Proteomic Analysis of Lungs in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment

Chao Qin, Guolin Wang, Hongguang Chen, Keliang Xie, Yang Yu, Yingxue Bian, Yonghao Yu, Yuchang Xin

Sepsis-associated acute lung injury (ALI), which carries a high morbidity and mortality in patients, has no effective therapeutic strategies to date. Our group has already...

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Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports

Bunpei Sato, Fumitake Satoh, Shin-Ichi Hirano, Yoshiyasu Takefuji, Yusuke Ichikawa

No abstract available Publish Year 2024 Country Japan Rank Positive Journal Medical Gas Research Primary Topic Brain Secondary TopicChronic Fatigue Syndrome Model Human Tertiary TopicChronic...

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Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway

Jin Zhang, Xiuying Wu, Ze Zhang, Zhiling Fu

Background. Hydrogen-rich saline (HRS) has strong anti-inflammatory, antioxidative stress, and antiapoptotic properties. The study focused on the protection of HRS on lipopolysaccharide (LPS)-induced acute lung...

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Efficacy and Safety of Hydrogen Therapy in Patients with Early-Stage Interstitial Lung Disease: A Single-Center, Randomized, Parallel-Group Controlled Trial

Chang Tang, Chenggong Guan, Fanping Yang, Haiqing Gao, Jin Yang, Lanting Wang, Li Ma, Lin Tang, Qiaozhi Gu, Shan He, Shengan Chen, Xiaoqun Luo, Ying Zhao, Yu Xu, Zhen Zhang, Zihua Chen

Purpose: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy...

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