The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Duried Alwazeer, Ebru Karadag Sari, Menekse Bulut, Mushap Kuru, Mustafa Makav, Sukran Yediel Aras

Research question: What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)? Design: Female rats were divided into four groups, each...

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Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19: A retrospective study of medical records

Dafeng Chen, Peng Luo, Qing He, Shian Huang, Wei Lei, Yuan He, Yuanfang Ding, Zufeng Huang

A global public health crisis caused by the 2019 novel coronavirus disease (COVID-19) leads to considerable morbidity and mortality, which bring great challenge to respiratory...

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The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa

Meizhu Chen, Qian Ye, Sheng Zhang, Weiming Yan, Xiaohong Chen, Xingchui Lin, Yanjian Chen, Yunpeng Wang

Objective: To investigate the feasibility and effectiveness of hydrogen in the treatment of retinitis pigmentosa (RP) patients through the drinking of hydrogen-rich water (HRW). Methods:...

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Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

Andrew McKune, Barbora Sladeckova, Dalibor Pastucha, Iva Klimesova, Jakub Krejci, Michal Botek, Michal Valenta, Petr Konecny

Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties....

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Inhibition of retinal ischemia-reperfusion injury in rats by inhalation of low-concentration hydrogen gas

Atsushi Hayashi, Kenichi Arai, Mitsuya Otsuka, Yoshiko Yoshida

Purpose: To investigate the inhibitory effect of hydrogen gas inhalation on retinal ischemia reperfusion (I/R) injury using a rat model. Methods: Six-week-old male Sprague-Dawley rats...

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Hydrogen inhalation promotes recovery of a patient in persistent vegetative state from intracerebral hemorrhage: A case report and literature review

Feng-Ming Xiao, Hai-Feng Wei, Jing Qiao, Wen-Jie Tang, Yan Huang, You-Zhen Wei, Yuan-Yun Xie

Background: Persistent vegetative state (PVS) is a devastating and long-lasting clinical condition with high morbidity and mortality; currently, there are no available effective interventions. Case...

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Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway

Cong-Cong Zhang, Guang Shi, Jing Wang, Rong Chen, Xiang-Jian Zhang, Yuan-Yuan Du

This study explored the protective effect and mechanism of hydrogen‑rich saline (HRS) on the neurological function of mice with cerebral ischemia. Effects of HRS on...

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Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition

Hongguang Chen, Kuibin Xu, Ruichen Shu, Xiaobei Zhang, Xiaofeng Liu, Yonghao Yu, Yuan Li

Background: Pulmonary microvascular endothelial cells (PMVECs) are initial targets of sepsis-induced acute lung injury (ALI). During the apoptosis of PMVECs, tight junctions (TJ) and adherens...

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Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats

Huan Liu, Hui Yuan, Jianguo Li, Mengya Liu, Xiaoman Chen, Xiaoming Liu, Xiujun Qin, Yong Wang

Background: Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms...

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Effects of hydrogen on the lung damage of mice at early stage of severe burn

C. Qin, J.H. Zhang, T.T. Feng, Y.H. Yu, Y.X. Bian

Objective: To investigate the effects of hydrogen on the lung damage of mice at early stage of severe burn. Methods: One hundred and sixty ICR...

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Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study

Alex Tarnava, Ghizal Fatima, Jan Fedacko, Ram B. Singh, Tyler W. LeBaron, Viliam Mojto

Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and...

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The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial

Feng Sun, Hong Bao, Hui Chen, Jie-Ming Qu, Meng-Meng Shi, Qing-Yun Li, Rong Chen, Ting Cheng, Wei-Ning Xiong, Xiao-Dan Wang, Yuan-Lin Song, Yun-Feng Zhang, Yun-Tian Chen

Clinical studies had found that hydrogen/oxygen mixed inhalation was beneficial to ameliorate the respiratory symptoms in the adjuvant treatment of patients with COVID-19. We aimed...

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