The condition of the hairline of Chinchilla lanigera after the introduction of a hydrogen antioxidant into the diet

Alexey Ivanov, Dmitry Petrov, Elena Panina

It was found that the inclusion of water enriched with molecular hydrogen into the diet of a long-tailed chinchilla changed the fur quality indicators. In...

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Hydrogen-Rich Saline-A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro

Cong Zhang, Huimin Qiao, Jing Wang, Lan Yang, Lan Zhang, Linyu Chen, Peipei Zhang, Renhao Xu, Wei Jiang, Xiangjian Zhang, Yuanyuan Du

Background: Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3...

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In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas

Bo-Yan Liu, Jun-Li Xue, Meng-Yu Zhang, Min Zhao, Ming-Yue Wang, Qian-Qian Gu, Shu-Cun Qin, Yun Wang

Medical effects of hydrogen have been reported in many studies. Due to difficulties in measuring hydrogen concentration in vivo after intake and high explosive risks...

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Hydrogen-rich water reduces cell damage by reducing excessive autophagy in mouse neuronal cells after oxygen glucose deprivation/reoxygenation

Junling Tao, Shixin Li, Yehong Li, Ying Liu

Objective: To investigate whether hydrogen-rich water exerts a protective effect against cellular injury by affecting the level of autophagy after oxygen glucose deprivation/reoxygenation (OGD/R) in...

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Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum

Li Xiao, Nobuhiko Miwa, Yoshiharu Tanaka

This study compared the effects of hydrogen-water (HW) bath on the oxygen radical absorption-based antioxidant capacity and the inflammatory indicator, C-reactive protein (CRP), in serum...

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Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study

Bing Liang, Dongyue Du, Hongbin Kang, Hua Li, Jiangang Long, Jianjiao Cui, Jiankang Liu, Le Shi, Mami Noda, Ning Yi, Ping Li, Shucun Qin, Xuejun Sun, Yue Xi

Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models....

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Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs

Akeo Hirai, Eiji Kobayashi, Genki Ichihara, Hidenori Moriyama, Hiroki Kitakata, Kenichiro Kinouchi, Mizuki Momoi, Motoaki Sano, Seien Ko, Yoshiki Shinya, Yoshinori Katsumata

Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich water in neuropsychiatric and endocrine...

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Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

Cheol-Su Kim, Eun Sook Jeong, Johny Bajgal, Kyu-Jae Lee, Md Habibur Rahman, Seong Hoon Goh, Subham Sharma, Yeon-Gyu Jang

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including...

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The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs

Dong-Dong Qi, Jian-Tao Zhang, Meng-Yuan Ding, Muhammad Abid Hayat, Tao Liu, Ting Wang

This study explored the effects of drinking Hydrogen-rich water (HRW) on skin wound healing in dogs. Eight circular wounds were analyzed in each dog. The...

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Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model

Eri Inoue, Kenichi Ohta, Kosuke Koyano, Kota Inoue, Makoto Arioka, Masaki Ueno, Shinji Nakamura, Takanori Miki, Takashi Kusaka, Takayuki Yokota, Toi Tsuchiya, Tsutomu Mitsuie, Yasuhiro Nakao, Yinmon Htun, Yukihiko Konishi

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns in both high- and low-income countries. The important determinants of its...

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Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis

Berengere J.C. Luthringer-Feyerabend, Hao Wang, Hongzhou Peng, Jiahua Ni, Jiazeng Xia, Jun Yan, Rui Zan, Weijie Cai, Weiping Ji, Wenhui Wang, Xiaonong Zhang, Yang Song

Hydrogen has been used to suppress tumor growth with considerable efficacy. Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic...

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Hydrogen Attenuates Inflammation by Inducing Early M2 Macrophage Polarization in Skin Wound Healing

Fei Xie, Mengyu Liu, Pengxiang Zhao, Shidong Lu, Xuemei Ma, Xujuan Zhang, Zisong Cai, Ziyi Liu

The heterogeneous and highly plastic cell populations of macrophages are important mediators of cellular responses during all stages of wound healing, especially in the inflammatory...

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