A Comparison of the Antioxidant Effects Between Hydrogen Gas Inhalation and Vitamin C Supplementation in Response to a 60-Min Treadmill Exercise in Rat Gastrocnemius Muscle

Chaoqun Li, Li Wen, Shi Zhou, Yuqi Zhao, Zhenghui Yu

The reactive oxygen species (ROS) produced during exercise act as a double-edged sword because they may cause oxidative damage but also play a role in...

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Space Station-like Composite Nanoparticles for Co-Delivery of Multiple Natural Compounds from Chinese Medicine and Hydrogen in Combating Sensorineural Hearing Loss

Chong Yu, Gang Chen, Hanqi Li, Kerui He, Liye Xia, Lu Wen, Ming Zhang, Pei Luo, Shibao Xie, Wenbin Xiao, Zeming Zhou, Zhifeng Zhang

Ototoxic drugs such as aminoglycoside antibiotics and cisplatin (CDDP) can cause sensorineural hearing loss (SNHL), which is closely related to oxidative stress and the acidification...

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Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice

Boyan Liu, Jun Chen, Junli Xue, Min Zhao, Shucun Qin, Xiaoyi Zhang, Xiubin Jia, Yiwei Wang, Yunbo Xie

Background: Molecular hydrogen (H2) has been recognized as an effective antioxidant with no or little side effects. While it is known that oxidative stress is...

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Efficacy of donepezil plus hydrogen-oxygen mixture inhalation for treatment of patients with Alzheimer disease: A retrospective study

Haifeng Li, Jin Xie, Zhaojun Dan

To investigate the clinical effect of donepezil combined with hydrogen-oxygen mixture inhalation in the treatment of patients with Alzheimer disease (AD), a total of 273...

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The effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury

Akihiko Taniguchi, Atsunori Nakao, Hiromichi Naito, Ikuroh Ohsawa, Masumi Iketani, Michiko Ishikawa, Mizuki Seya, Nobuaki Miyahara, Takahiro Hirayama, Toshiyuki Aokage, Tsuyoshi Nojima, Yasuhiro Terasaki

Background: Acute respiratory distress syndrome, which is caused by acute lung injury, is a destructive respiratory disorder caused by a systemic inflammatory response. Persistent inflammation...

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APOA2: New Target for Molecular Hydrogen Therapy in Sepsis-Related Lung Injury Based on Proteomic and Genomic Analysis

Enquan Wang, Feier Wu, Hongguang Chen, Keliang Xie, Yan Fan, Yi Jiang, Yonghao Yu, Yu Song, Yuanlin Wang

Target biomarkers for H2 at both the protein and genome levels are still unclear. In this study, quantitative proteomics acquired from a mouse model were...

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Evaluation of the hydrogen-rich water alleviation potential on mercury toxicity in earthworms using ATR-FTIR and LC-ESI-MS/MS spectroscopy

Arzu Odunkiran, Duried Alwazeer, Mehmet Nuri Atalar, Menekse Bulut, Mine Kokturk

The toxic effects of mercury in earthworms and the potential alleviation effect of hydrogen-rich water (HRW) using ATR-FTIR and LC-MS analysis methods were investigated. Different...

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Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery

Barbora Kalocayova, Branislav Kura, Denisa Snurikova, Ivo Gasparovic, Jan Slezak, Jana Vlkovicova, Jaroslav Luptak, Karel Frimmel, Matej Ondrusek, Michal Hulman, Norbert Vrbjar, Rastislav Sramaty, Tyler W. LeBaron, Vladan Hudec

Cardiac surgery-associated acute kidney injury (CS-AKI) is a common postoperative complication, mostly due increasing oxidative stress. Recently, molecular hydrogen (H2 gas), has also been applied...

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Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia

Cheng Cheng, Chuan Zhao, Ruoxi Wang, Xiangmei Chen, Yushu Guo

The present study aims to investigate the impact of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia. Thirty Sprague-Dawley rats...

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Coral calcium carried hydrogen ameliorates the severity of non-alcoholic steatohepatitis induced by a choline deficient high carbohydrate fat-free diet in elderly rats

Daisuke Ueda, Kuai Ma, Masayuki Fujino, Naotsugu Ichimaru, Neiki Nambu, Xiao-Kang Li, Xin Hu

Hydrogen has been reported to act as an antioxidant, anti-apoptosis and anti-inflammatory agent. Coral calcium carried hydrogen (G2-SUISO) is a safer and more convenient form...

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Hydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation

Daihong Liu, Jiaxin Liu, Li-Ren Qian, Weina Ma, Xiaona Wang, Yu Liu

Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment option for various hematopoietic diseases and certain hereditary diseases. Chronic graft-versus-host disease (cGVHD) has...

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Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation

Alexandra Olimpio Siquera Cunha, Aline Alves Jesus, Evelin Capellari Carnio, Junia Lara de Deus, Luiz G. S. Branco, Mateus Ramos Amorim, Procopio Cleber Gama de Barcellos Filho, Ricardo Mauricio Leao, Rui Milton Patricio da Silva Junior

Sepsis is associated with numerous physiological and biochemical abnormalities that result in a life-threatening condition. The involvement of the Central Nervous System (CNS) during sepsis...

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