Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial

Hisashi Kosaka, Masaki Kaibori

Introduction: Molecular hydrogen had been considered inactive in vivo but is an antioxidant that selectively reduces highly toxic reactive oxygen species (ROS). Animal studies have...

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Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

Beibei Dong, Wen Mi, Xiaoyin Meng, Yi Jiang, Yonghao Yu, Yuanyuan Bai, Yuechun Lu

Hydrogen (H2) can protect against blood‒brain barrier (BBB) damage in sepsis-associated encephalopathy (SAE), but the mechanism is still unclear. We examined whether it is related...

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Effects of Natural Reduced Water on Cognitive Function, Body Composition, and Psychological Function in Older Adults: Study Protocol for a Randomized Controlled Trial

Hikari Iki, Keisuke Kokubun, Takamitsu Shinada, Yasuyuki Taki, Yuji Takano

Natural reduced water is natural water that contains active hydrogen and reduces oxidation. It is rare in the world, and in Japan, it is produced...

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Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis

Binyi An, Fang Liu, Hong Sang, Nan Hong, Pan Yu, Qingtao Kong, Xinyu Zhang, Yingying Wu, Yuxin Shan

The purpose of this study was to investigate whether hydrogen-rich bath has therapeutic effect on psoriasis and its molecular mechanism. Mice with imiquimod-induced psoriasis were...

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Influence of molecular hydrogen on behavioral adaptation of Сhinchilla lanigera taking into account gender factor in conditions of cage keeping

Alexey Ivanov, Dmitry Petrov, Elena Panina, Nadezdha Panteleeva

It was found that the inclusion of water enriched with molecular hydrogen in the diet of animals increased the overall proportion of active behavior. According...

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Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-Arm, Retrospective Study

Hongxiang Ji, Ruitao Sun, Tongshang Ni, Xiaoheng Ding, Yuquan Li, Zeyu Liu, Ziyi Zhao

Aim: To evaluate the real-life effectiveness and safety of Chinese patients with type 2 diabetes mellitus (T2DM) receiving hydrogen inhalation (HI) treatment as a supplementary...

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Hydra V Hydrogen Experimental Dive To 450 Meters

C. Cortan, H.G. Delauze

HYDRAV was performed in COMEX Marseille hyperbaric Research Center in May and June 1985.During this Experiment, 6 divers lived at a simulated depth of 450...

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Hydrogen-generating Si-based agent improves fat graft survival in rats

Hikaru Kobayashi, Kazuya Kuroda, Koichi Tomita, Naoya Otani, Tateki Kubo, Yuki Kobayashi

Background: Regulating excessive inflammation and oxidative stress in fat grafting may improve retention rates. Hydrogen effectively combats oxidative stress and inflammation and reportedly inhibits ischemia-reperfusion...

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Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis

Jingyi Shi, Junmei Zhou, Lulu Zheng, Qingfeng Sheng, Shenghua Yu, Xueli Wang, Zhibao Lv, Zhimei Gao

Background: Hydrogen is protective against intestinal injury in necrotizing enterocolitis (NEC), mainly through to alleviate inflammation response. The M1 macrophages can promote inflammation. We hypothesized...

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Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery

Chao Xia, Lingting Zeng, Min Zhao, Qianjun He, Shengqiang Chen, Shucun Qin, Zhaokui Jin

The metabolic disorder of hepatocytes in non-alcoholic fatty liver disease (NAFLD) leads to the formation of an iron pool which induces the Fenton reaction-derived ferroptosis...

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Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis

Qiang Wan, Tian Sun, Ting-Ting Li, Wan-Chao Yang, Wen-Zhi Li, Yue-Zhen Wang

Background: Traumatic brain injury (TBI)-induced acute lung injury (ALI) is a critical condition, and inflammation and apoptosis play essential roles. Molecular hydrogen (H2) exerts anti-inflammatory...

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Hydrogen-rich water treatment targets RT1-Db1 and RT1-Bb to alleviate premature ovarian failure in rats

Lu Zhao, Shuai Zhang, Xiaoyin Meng, Yingmei Wang

Background: Premature ovarian failure (POF) is defined as the cessation of ovarian function before the age of 40 years, imposing a significant health burden on...

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